About Protein furry homolog-like
Protein furry homolog-like (FRYL) is a protein
from Homo sapiens identified by UniProt accession
O94915, 3013 residues long.
MolForge cross-references it against 0 known binders and
173 disease associations.
Target properties
| Protein name | Protein furry homolog-like |
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| UniProt accession | O94915 |
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| Gene | FRYL |
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| Organism | Homo sapiens |
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| Length | 3013 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (173)
Diseases linked to this target (Open Targets).
- body height · score 0.42
- platelet count · score 0.36
- systolic blood pressure · score 0.30
- age at menopause · score 0.28
- cortical surface area measurement · score 0.26
- hemoglobin measurement · score 0.25
- mean platelet volume · score 0.21
- brain measurement · score 0.20
- hematocrit · score 0.19
- sitting height measurement · score 0.19
3D Structure (10)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
Amino-acid sequence (3013 residues)
MSNITIDPDV KPGEYVIKSL FAEFAVQAEK KIEVVMAEPL EKLLSRSLQR GEDLQFDQLI SSMSSVAEHC LPSLLRTLFD WYRRQNGTED ESYEYRPRSS TKSKGDEQQR ERDYLLERRD LAVDFIFCLV LVEVLKQIPV HPVPDPLVHE VLNLAFKHFK HKEGYSGTNT GNVHIIADLY AEVIGVLAQS KFQAVRKKFV TELKELRQKE QSPHVVQSVI SLIMGMKFFR VKMYPVEDFE ASFQFMQECA QYFLEVKDKD IKHALAGLFV EILIPVAAAV KNEVNVPCLK NFVEMLYQTT FELSSRKKHS LALYPLITCL LCVSQKQFFL NNWHIFLQNC LSHLKNKDPK MSRVALESLY RLLWVYVIRI KCESNTVTQS RLMSIVSALF PKGSRSVVPR DTPLNIFVKI IQFIAQERLD FAMKEIIFDL LSVGKSTKTF TINPERMNIG LRVFLVIADS LQQKDGEPPM PTTGVILPSG NTLRVKKIFL NKTLTDEEAK VIGMSVYYPQ VRKALDSILR HLDKEVGRPM CMTSVQMSNK EPEDMITGER KPKIDLFRTC IAAIPRLIPD GMSRTDLIEL LARLTIHMDE ELRALAFNTL QALMLDFPDW REDVLSGFVY FIVREVTDVH PTLLDNAVKM LVQLINQWKQ AAQMHNKNQD TQHGVANGAS HPPPLERSPY SNVFHVVEGF ALVILCSSRP ATRRLAVSVL REIRALFALL EIPKGDDELA IDVMDRLSPS ILESFIHLTG ADQTTLLYCP SSIDLQTLAE WNSSPISHQF DVISPSHIWI FAHVTQGQDP WIISLSSFLK QENLPKHCST AVSYAWMFAY TRLQLLSPQV DINSPINAKK VNTTTSSDSY IGLWRNYLIL CCSAATSSSS TSAGSVRCSP PETLASTPDS GYSIDSKIIG IPSPSSLFKH IVPMMRSESM EITESLVLGL GRTNPGAFRE LIEELHPIIK EALERRPENM KRRRRRDILR VQLVRIFELL ADAGVISHSA SGGLDNETHF LNNTLLEYVD LTRQLLEAEN EKDSDTLKDI RCHFSALVAN IIQNVPVHQR RSIFPQQSLR HSLFMLFSHW AGPFSIMFTP LDRYSDRNMQ INRHQYCALK AMSAVLCCGP VADNVGLSSD GYLYKWLDNI LDSLDKKVHQ LGCEAVTLLL ELNPDQSNLM YWAVDRCYTG SGRVAAGCFK AIANVFQNRD YQCDTVMLLN LILFKAADSS RSIYEVAMQL LQILEPKMFR YAHKLEVQRT DGVLSQLSPL PHLYSVSYYQ LSEELARAYP ELTLAIFSEI SQRIQTAHPA GRQVMLHYLL PWMNNIELVD LKPLPTARRH DEDEDDSLKD RELMVTSRRW LRGEGWGSPQ ATAMVLNNLM YMTAKYGDEL AWSEVENVWT TLADGWPKNL KIILHFLISI CGVNSEPSLL PYVKKVIVYL GRDKTMQLLE ELVSELQLTD PVSSGVTHMD NPPYYRITSS YKIPSVTSGT TSSSNTMVAP TDGNPDNKPI KENIEESYVH LDIYSGLNSH LNRQHHRLES RYSSSSGGSY EEEKSDSMPL YSNWRLKVME HNQGEPLPFP PAGGCWSPLV DYVPETSSPG LPLHRCNIAV ILLTDLIIDH SVKVEWGSYL HLLLHAIFIG FDHCHPEVYE HCKRLLLHLL IVMGPNSNIR TVASVLLRNK EFNEPRVLTV KQVAHLDYNF TAGINDFIPD YQPSPMTDSG LSSSSTSSSI SLGNNSAAIS HLHTTILNEV DISVEQDGKV KTLMEFITSR KRGPLWNHED VSAKNPSIKS AEQLTTFLKH VVSVFKQSSS EGIHLEHHLS EVALQTALSC SSRHYAGRSF QIFRALKQPL TATTLSDVLS RLVETVGDPG EDAQGFVIEL LLTLESAIDT LAETMKHYDL LSALSQTSYH DPIMGNKYAA NRKSTGQLNL STSPINSSSY LGYNSNARSN SLRLSLIGDR RGDRRRSNTL DIMDGRINHS SSLARTRSLS SLREKGMYDV QSTTEPTNLM ATIFWIAASL LESDYEYEYL LALRLLNKLL IHLPLDKSES REKIENVQSK LKWTNFPGLQ QLFLKGFTSA STQEMTVHLL SKLISVSKHT LVDPSQLSGF PLNILCLLPH LIQHFDSPTQ FCKETASRIA KVCAEEKCPT LVNLAHMMSL YSTHTYSRDC SNWINVVCRY LHDSFSDTTF NLVTYLAELL EKGLSSMQQS LLQIIYSLLS HIDLSAAPAK QFNLEIIKII GKYVQSPYWK EALNILKLVV SRSASLVVPS DIPKTYGGDT GSPEISFTKI FNNVSKELPG KTLDFHFDIS ETPIIGNKYG DQHSAAGRNG KPKVIAVTRS TSSTSSGSNS NALVPVSWKR PQLSQRRTRE KLMNVLSLCG PESGLPKNPS VVFSSNEDLE VGDQQTSLIS TTEDINQEEE VAVEDNSSEQ QFGVFKDFDF LDVELEDAEG ESMDNFNWGV RRRSLDSIDK GDTPSLQEYQ CSSSTPSLNL TNQEDTDESS EEEAALTASQ ILSRTQMLNS DSATDETIPD HPDLLLQSED STGSITTEEV LQIRDETPTL EASLDNANSR LPEDTTSVLK EEHVTTFEDE GSYIIQEQQE SLVCQGILDL EETEMPEPLA PESYPESVCE EDVTLALKEL DERCEEEEAD FSGLSSQDEE EQDGFPEVQT SPLPSPFLSA IIAAFQPVAY DDEEEAWRCH VNQMLSDTDG SSAVFTFHVF SRLFQTIQRK FGEITNEAVS FLGDSLQRIG TKFKSSLEVM MLCSECPTVF VDAETLMSCG LLETLKFGVL ELQEHLDTYN VKREAAEQWL DDCKRTFGAK EDMYRINTDA QQMEILAELE LCRRLYKLHF QLLLLFQAYC KLINQVNTIK NEAEVINMSE ELAQLESILK EAESASENEE IDISKAAQTT IETAIHSLIE TLKNKEFISA VAQVKAFRSL WPSDIFGSCE DDPVQTLLHI YFHHQTLGQT GSFAVIGSNL DMSEANYKLM ELNLEIRESL RMVQSYQLLA QAKPMGNMVS TGF
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