Endonuclease domain-containing 1 protein (ENDOD1)

About Endonuclease domain-containing 1 protein

Endonuclease domain-containing 1 protein (ENDOD1) is a protein from Homo sapiens identified by UniProt accession O94919, 500 residues long. MolForge cross-references it against 0 known binders and 48 disease associations.

Target properties

Protein name	Endonuclease domain-containing 1 protein
UniProt accession	O94919
Gene	ENDOD1
Organism	Homo sapiens
Length	500 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (48)

Diseases linked to this target (Open Targets).

mean platelet volume · score 0.48
reticulocyte count · score 0.47
platelet count · score 0.45
reticulocyte measurement · score 0.41
Red cell distribution width · score 0.39
heel bone mineral density · score 0.34
mean corpuscular volume · score 0.30
puberty onset measurement · score 0.29
mean corpuscular hemoglobin · score 0.28
erythrocyte count · score 0.27

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O94919-F1	alphafold	PREDICTED	80.85	—

Amino-acid sequence (500 residues)

MGTARWLALG SLFALAGLLE GRLVGEEEAG FGECDKFFYA GTPPAGLAAD SHVKICQRAE GAERFATLYS TRDRIPVYSA FRAPRPAPGG AEQRWLVEPQ IDDPNSNLEE AINEAEAITS VNSLGSKQAL NTDYLDSDYQ RGQLYPFSLS SDVQVATFTL TNSAPMTQSF QERWYVNLHS LMDRALTPQC GSGEDLYILT GTVPSDYRVK DKVAVPEFVW LAACCAVPGG GWAMGFVKHT RDSDIIEDVM VKDLQKLLPF NPQLFQNNCG ETEQDTEKMK KILEVVNQIQ DEERMVQSQK SSSPLSSTRS KRSTLLPPEA SEGSSSFLGK LMGFIATPFI KLFQLIYYLV VAILKNIVYF LWCVTKQVIN GIESCLYRLG SATISYFMAI GEELVSIPWK VLKVVAKVIR ALLRILCCLL KAICRVLSIP VRVLVDVATF PVYTMGAIPI VCKDIALGLG GTVSLLFDTA FGTLGGLFQV VFSVCKRIGY KVTFDNSGEL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards