About Cyclin-dependent kinase 14
Cyclin-dependent kinase 14 (CDK14) is a protein
from Homo sapiens identified by UniProt accession
O94921, 469 residues long.
MolForge cross-references it against 0 known binders and
82 disease associations.
Target properties
| Protein name | Cyclin-dependent kinase 14 |
|---|
| UniProt accession | O94921 |
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| Gene | CDK14 |
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| Organism | Homo sapiens |
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| Length | 469 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Approved drugs hitting this target (5)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (82)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.46
- systolic blood pressure · score 0.35
- pulse pressure measurement · score 0.28
- hepatocellular carcinoma · score 0.24
- hepatitis B virus infection · score 0.23
- attention deficit hyperactivity disorder · score 0.22
- antisocial behaviour measurement · score 0.22
- substance abuse · score 0.22
- protein measurement · score 0.17
- neoplasm · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O94921-F1 | alphafold | PREDICTED | 70.70 | — |
Amino-acid sequence (469 residues)
MCDLIEPQPA EKIGKMKKLR RTLSESFSRI ALKKDDTTFD EICVTKMSTR NCQGMDSVIK PLDTIPEDKK VRVQRTQSTF DPFEKPANQV KRVHSENNAC INFKTSSTGK ESPKVRRHSS PSSPTSPKFG KADSYEKLEK LGEGSYATVY KGKSKVNGKL VALKVIRLQE EEGTPFTAIR EASLLKGLKH ANIVLLHDII HTKETLTLVF EYVHTDLCQY MDKHPGGLHP DNVKLFLFQL LRGLSYIHQR YILHRDLKPQ NLLISDTGEL KLADFGLARA KSVPSHTYSN EVVTLWYRPP DVLLGSTEYS TCLDMWGVGC IFVEMIQGVA AFPGMKDIQD QLERIFLVLG TPNEDTWPGV HSLPHFKPER FTLYSSKNLR QAWNKLSYVN HAEDLASKLL QCSPKNRLSA QAALSHEYFS DLPPRLWELT DMSSIFTVPN VRLQPEAGES MRAFGKNNSY GKSLSNSKH
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