About D-glucuronyl C5-epimerase
D-glucuronyl C5-epimerase (GLCE) is a protein
from Homo sapiens identified by UniProt accession
O94923, 617 residues long.
MolForge cross-references it against 0 known binders and
94 disease associations.
Target properties
| Protein name | D-glucuronyl C5-epimerase |
|---|
| UniProt accession | O94923 |
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| Gene | GLCE |
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| Organism | Homo sapiens |
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| Length | 617 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (94)
Diseases linked to this target (Open Targets).
- erythrocyte count · score 0.29
- blood protein measurement · score 0.29
- peak expiratory flow · score 0.26
- hypertension · score 0.24
- appendicular lean mass · score 0.23
- mean corpuscular hemoglobin · score 0.21
- red blood cell density measurement · score 0.16
- mean corpuscular volume · score 0.06
- lymphocyte percentage of leukocytes · score 0.06
- mean corpuscular hemoglobin concentration · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O94923-F1 | alphafold | PREDICTED | 88.51 | — |
Amino-acid sequence (617 residues)
MRCLAARVNY KTLIIICALF TLVTVLLWNK CSSDKAIQFP RRSSSGFRVD GFEKRAAASE SNNYMNHVAK QQSEEAFPQE QQKAPPVVGG FNSNVGSKVL GLKYEEIDCL INDEHTIKGR REGNEVFLPF TWVEKYFDVY GKVVQYDGYD RFEFSHSYSK VYAQRAPYHP DGVFMSFEGY NVEVRDRVKC ISGVEGVPLS TQWGPQGYFY PIQIAQYGLS HYSKNLTEKP PHIEVYETAE DRDKNKPNDW TVPKGCFMAN VADKSRFTNV KQFIAPETSE GVSLQLGNTK DFIISFDLKF LTNGSVSVVL ETTEKNQLFT IHYVSNAQLI AFKERDIYYG IGPRTSWSTV TRDLVTDLRK GVGLSNTKAV KPTKIMPKKV VRLIAKGKGF LDNITISTTA HMAAFFAASD WLVRNQDEKG GWPIMVTRKL GEGFKSLEPG WYSAMAQGQA ISTLVRAYLL TKDHIFLNSA LRATAPYKFL SEQHGVKAVF MNKHDWYEEY PTTPSSFVLN GFMYSLIGLY DLKETAGEKL GKEARSLYER GMESLKAMLP LYDTGSGTIY DLRHFMLGIA PNLARWDYHT THINQLQLLS TIDESPVFKE FVKRWKSYLK GSRAKHN
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