About Glutaminase kidney isoform, mitochondrial
Glutaminase kidney isoform, mitochondrial (GLS) is a protein
from Homo sapiens identified by UniProt accession
O94925, 669 residues long.
MolForge cross-references it against 0 known binders and
372 disease associations.
Target properties
| Protein name | Glutaminase kidney isoform, mitochondrial |
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| UniProt accession | O94925 |
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| Gene | GLS |
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| Organism | Homo sapiens |
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| Length | 669 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (372)
Diseases linked to this target (Open Targets).
- global developmental delay, progressive ataxia, and elevated glutamine · score 0.61
- infantile cataract, skin abnormalities, glutamate excess, and impaired intellectual development · score 0.51
- developmental and epileptic encephalopathy · score 0.50
- mean platelet volume · score 0.46
- BMI-adjusted waist-hip ratio · score 0.44
- reticulocyte count · score 0.43
- body height · score 0.43
- reticulocyte measurement · score 0.38
- neurodegenerative disease · score 0.37
- glutaminase deficiency · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O94925-F1 | alphafold | PREDICTED | 80.20 | — |
Amino-acid sequence (669 residues)
MMRLRGSGML RDLLLRSPAG VSATLRRAQP LVTLCRRPRG GGRPAAGPAA AARLHPWWGG GGWPAEPLAR GLSSSPSEIL QELGKGSTHP QPGVSPPAAP AAPGPKDGPG ETDAFGNSEG KELVASGENK IKQGLLPSLE DLLFYTIAEG QEKIPVHKFI TALKSTGLRT SDPRLKECMD MLRLTLQTTS DGVMLDKDLF KKCVQSNIVL LTQAFRRKFV IPDFMSFTSH IDELYESAKK QSGGKVADYI PQLAKFSPDL WGVSVCTVDG QRHSTGDTKV PFCLQSCVKP LKYAIAVNDL GTEYVHRYVG KEPSGLRFNK LFLNEDDKPH NPMVNAGAIV VTSLIKQGVN NAEKFDYVMQ FLNKMAGNEY VGFSNATFQS ERESGDRNFA IGYYLKEKKC FPEGTDMVGI LDFYFQLCSI EVTCESASVM AATLANGGFC PITGERVLSP EAVRNTLSLM HSCGMYDFSG QFAFHVGLPA KSGVAGGILL VVPNVMGMMC WSPPLDKMGN SVKGIHFCHD LVSLCNFHNY DNLRHFAKKL DPRREGGDQR VKSVINLLFA AYTGDVSALR RFALSAMDME QRDYDSRTAL HVAAAEGHVE VVKFLLEACK VNPFPKDRWN NTPMDEALHF GHHDVFKILQ EYQVQYTPQG DSDNGKENQT VHKNLDGLL
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