About RING finger protein 37
RING finger protein 37 (UBOX5) is a protein
from Homo sapiens identified by UniProt accession
O94941, 541 residues long.
MolForge cross-references it against 0 known binders and
14 disease associations.
Target properties
| Protein name | RING finger protein 37 |
|---|
| UniProt accession | O94941 |
|---|
| Gene | UBOX5 |
|---|
| Organism | Homo sapiens |
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| Length | 541 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (14)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.53
- leukocyte count · score 0.22
- clear cell renal carcinoma · score 0.18
- wellbeing measurement · score 0.17
- self reported educational attainment · score 0.11
- Recurrent infection due to specific granule deficiency · score 0.03
- endometriosis · score 0.03
- Blackfan-Diamond anemia · score 0.03
- neutropenia, severe congenital, 2, autosomal dominant · score 0.03
- neutropenia, severe congenital, 1, autosomal dominant · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O94941-F1 | alphafold | PREDICTED | 70.60 | — |
Amino-acid sequence (541 residues)
MVINLCLPQF RPRIHCNKIS ADGYEVENLI SEDLTKRSHG FRTEYFIKPP VYVTVSFPFN VEICRINIDL TAGGGQNVTG LEMYTSASSS RVSWNTPQCR TLGPAEPSVP DKEAFTLVGK VLLKNQSQVV FSHRGFKARP PFGAMEATLP SPAVVAQELW NKGALSLSHV AHLRICITHV TGGGIPCIKR LEVWGQPAKT CSQEVIDSIL LVTSENLPQD VALQAPALPM ESDCDPGDQP ESQQAPSSLQ KLAEIIQDVP EEFLDPITLE IMPCPMLLPS GKVIDQSTLE KCNRSEATWG RVPSDPFTGV AFTPHSQPLP HPSLKARIDH FLLQHSIPGC HLLGRAQTAL AVIPSSIVLP SQKRKIEQAE HVPDSNFGVN ASCFSATSPL VLPTTSEHTA KKMKATNEPS LTHMDCSTGP LSHEQKLSQS LEIALASTLG SMPSFTARLT RGQLQHLGTR GSNTSWRPGT GSEQPGSILG PECASCKRVF SPYFKKEPVY QLPCGHLLCR PCLGEKQRSL PMTCTACQRP VASQDVLRVH F
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