About F-box only protein 21
F-box only protein 21 (FBXO21) is a protein
from Homo sapiens identified by UniProt accession
O94952, 628 residues long.
MolForge cross-references it against 0 known binders and
87 disease associations.
Target properties
| Protein name | F-box only protein 21 |
|---|
| UniProt accession | O94952 |
|---|
| Gene | FBXO21 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 628 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (87)
Diseases linked to this target (Open Targets).
- hemoglobin measurement · score 0.46
- body mass index · score 0.45
- hematocrit · score 0.41
- erythrocyte count · score 0.40
- red blood cell density measurement · score 0.38
- neurodegenerative disease · score 0.37
- pancreatic adenocarcinoma · score 0.18
- clear cell renal carcinoma · score 0.18
- neuroticism measurement · score 0.15
- depressive symptom measurement · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O94952-F1 | alphafold | PREDICTED | 85.25 | — |
Amino-acid sequence (628 residues)
MAAAAVDSAM EVVPALAEEA APEVAGLSCL VNLPGEVLEY ILCCGSLTAA DIGRVSSTCR RLRELCQSSG KVWKEQFRVR WPSLMKHYSP TDYVNWLEEY KVRQKAGLEA RKIVASFSKR FFSEHVPCNG FSDIENLEGP EIFFEDELVC ILNMEGRKAL TWKYYAKKIL YYLRQQKILN NLKAFLQQPD DYESYLEGAV YIDQYCNPLS DISLKDIQAQ IDSIVELVCK TLRGINSRHP SLAFKAGESS MIMEIELQSQ VLDAMNYVLY DQLKFKGNRM DYYNALNLYM HQVLIRRTGI PISMSLLYLT IARQLGVPLE PVNFPSHFLL RWCQGAEGAT LDIFDYIYID AFGKGKQLTV KECEYLIGQH VTAALYGVVN VKKVLQRMVG NLLSLGKREG IDQSYQLLRD SLDLYLAMYP DQVQLLLLQA RLYFHLGIWP EKSFCLVLKV LDILQHIQTL DPGQHGAVGY LVQHTLEHIE RKKEEVGVEV KLRSDEKHRD VCYSIGLIMK HKRYGYNCVI YGWDPTCMMG HEWIRNMNVH SLPHGHHQPF YNVLVEDGSC RYAAQENLEY NVEPQEISHP DVGRYFSEFT GTHYIPNAEL EIRYPEDLEF VYETVQNIYS AKKENIDE
Explore F-box only protein 21 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets