About Rho-related BTB domain-containing protein 3
Rho-related BTB domain-containing protein 3 (RHOBTB3) is a protein
from Homo sapiens identified by UniProt accession
O94955, 611 residues long.
MolForge cross-references it against 0 known binders and
63 disease associations.
Target properties
| Protein name | Rho-related BTB domain-containing protein 3 |
|---|
| UniProt accession | O94955 |
|---|
| Gene | RHOBTB3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 611 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (63)
Diseases linked to this target (Open Targets).
- reticulocyte count · score 0.26
- Immature Reticulocyte Fraction Measurement · score 0.21
- adolescent idiopathic scoliosis · score 0.18
- diffuse plaque measurement · score 0.14
- drug use measurement · score 0.12
- hemolysis · score 0.09
- reticulocyte measurement · score 0.09
- acute myeloid leukemia · score 0.08
- mean corpuscular hemoglobin · score 0.05
- mean corpuscular hemoglobin concentration · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O94955-F1 | alphafold | PREDICTED | 78.92 | — |
Amino-acid sequence (611 residues)
MSIHIVALGN EGDTFHQDNR PSGLIRTYLG RSPLVSGDES SLLLNAASTV ARPVFTEYQA SAFGNVKLVV HDCPVWDIFD SDWYTSRNLI GGADIIVIKY NVNDKFSFHE VKDNYIPVIK RALNSVPVII AAVGTRQNEE LPCTCPLCTS DRGSCVSTTE GIQLAKELGA TYLELHSLDD FYIGKYFGGV LEYFMIQALN QKTSEKMKKR KMSNSFHGIR PPQLEQPEKM PVLKAEASHY NSDLNNLLFC CQCVDVVFYN PNLKKVVEAH KIVLCAVSHV FMLLFNVKSP TDIQDSSIIR TTQDLFAINR DTAFPGASHE SSGNPPLRVI VKDALFCSCL SDILRFIYSG AFQWEELEED IRKKLKDSGD VSNVIEKVKC ILKTPGKINC LRNCKTYQAR KPLWFYNTSL KFFLNKPMLA DVVFEIQGTT VPAHRAILVA RCEVMAAMFN GNYMEAKSVL IPVYGVSKET FLSFLEYLYT DSCCPAGIFQ AMCLLICAEM YQVSRLQHIC ELFIITQLQS MPSRELASMN LDIVDLLKKA KFHHSDCLST WLLHFIATNY LIFSQKPEFQ DLSVEERSFV EKHRWPSNMY LKQLAEYRKY IHSRKCRCLV M
Explore Rho-related BTB domain-containing protein 3 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets