About Microtubule cross-linking factor 2
Microtubule cross-linking factor 2 (MTCL2) is a protein
from Homo sapiens identified by UniProt accession
O94964, 1661 residues long.
MolForge cross-references it against 0 known binders and
40 disease associations.
Target properties
| Protein name | Microtubule cross-linking factor 2 |
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| UniProt accession | O94964 |
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| Gene | MTCL2 |
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| Organism | Homo sapiens |
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| Length | 1661 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (40)
Diseases linked to this target (Open Targets).
- age-related macular degeneration · score 0.08
- X-linked retinal dysplasia · score 0.08
- retinitis pigmentosa · score 0.07
- choroidal dystrophy, central areolar, 1 · score 0.06
- Familial exudative vitreoretinopathy · score 0.06
- severe early-childhood-onset retinal dystrophy · score 0.06
- age related macular degeneration 11 · score 0.06
- age related macular degeneration 4 · score 0.06
- age related macular degeneration 7 · score 0.06
- Leber congenital amaurosis · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O94964-F1 | alphafold | PREDICTED | 54.25 | — |
Amino-acid sequence (1661 residues)
MEAPAAEPPV RGCGPQPAPA PAPAPERKKS HRAPSPARPK DVAGWSLAKG RRGPGPGSAV ACSAAFSSRP DKKGRAVAPG ARGAGVRVAG VRTGVRAKGR PRSGAGPRPP PPPPSLTDSS SEVSDCASEE ARLLGLELAL SSDAESAAGG PAGVRTGQPA QPAPSAQQPP RPPASPDEPS VAASSVGSSR LPLSASLAFS DLTEEMLDCG PSGLVRELEE LRSENDYLKD EIEELRAEML EMRDVYMEED VYQLQELRQQ LDQASKTCRI LQYRLRKAER RSLRAAQTGQ VDGELIRGLE QDVKVSKDIS MRLHKELEVV EKKRARLEEE NEELRQRLIE TELAKQVLQT ELERPREHSL KKRGTRSLGK ADKKTLVQED SADLKCQLHF AKEESALMCK KLTKLAKEND SMKEELLKYR SLYGDLDSAL SAEELADAPH SRETELKVHL KLVEEEANLL SRRIVELEVE NRGLRAEMDD MKDHGGGCGG PEARLAFSAL GGGECGESLA ELRRHLQFVE EEAELLRRSS AELEDQNKLL LNELAKFRSE HELDVALSED SCSVLSEPSQ EELAAAKLQI GELSGKVKKL QYENRVLLSN LQRCDLASCQ STRPMLETDA EAGDSAQCVP APLGETHESH AVRLCRAREA EVLPGLREQA ALVSKAIDVL VADANGFTAG LRLCLDNECA DFRLHEAPDN SEGPRDTKLI HAILVRLSVL QQELNAFTRK ADAVLGCSVK EQQESFSSLP PLGSQGLSKE ILLAKDLGSD FQPPDFRDLP EWEPRIREAF RTGDLDSKPD PSRSFRPYRA EDNDSYASEI KELQLVLAEA HDSLRGLQEQ LSQERQLRKE EADNFNQKMV QLKEDQQRAL LRREFELQSL SLQRRLEQKF WSQEKNMLVQ ESQQFKHNFL LLFMKLRWFL KRWRQGKVLP SEGDDFLEVN SMKELYLLME EEEINAQHSD NKACTGDSWT QNTPNEYIKT LADMKVTLKE LCWLLRDERR GLTELQQQFA KAKATWETER AELKGHTSQM ELKTGKGAGE RAGPDWKAAL QREREEQQHL LAESYSAVME LTRQLQISER NWSQEKLQLV ERLQGEKQQV EQQVKELQNR LSQLQKAADP WVLKHSELEK QDNSWKETRS EKIHDKEAVS EVELGGNGLK RTKSVSSMSE FESLLDCSPY LAGGDARGKK LPNNPAFGFV SSEPGDPEKD TKEKPGLSSR DCNHLGALAC QDPPGRQMQR SYTAPDKTGI RVYYSPPVAR RLGVPVVHDK EGKIIIEPGF LFTTAKPKES AEADGLAESS YGRWLCNFSR QRLDGGSAGS PSAAGPGFPA ALHDFEMSGN MSDDMKEITN CVRQAMRSGS LERKVKSTSS QTVGLASVGT QTIRTVSVGL QTDPPRSSLH GKAWSPRSSS LVSVRSKQIS SSLDKVHSRI ERPCCSPKYG SPKLQRRSVS KLDSSKDRSL WNLHQGKQNG SAWARSTTTR DSPVLRNIND GLSSLFSVVE HSGSTESVWK LGMSETRAKP EPPKYGIVQE FFRNVCGRAP SPTSSAGEEG TKKPEPLSPA SYHQPEGVAR ILNKKAAKLG SSEEVRLTML PQVGKDGVLR DGDGAVVLPN EDAVCDCSTQ SLTSCFARSS RSAIRHSPSK CRLHPSESSW GGEERALPPS E
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