About WD repeat-containing protein 47
WD repeat-containing protein 47 (WDR47) is a protein
from Homo sapiens identified by UniProt accession
O94967, 919 residues long.
MolForge cross-references it against 0 known binders and
28 disease associations.
Target properties
| Protein name | WD repeat-containing protein 47 |
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| UniProt accession | O94967 |
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| Gene | WDR47 |
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| Organism | Homo sapiens |
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| Length | 919 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (28)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.48
- neurofibrillary tangles measurement · score 0.08
- hemoglobin D disease · score 0.03
- oligodendroglioma · score 0.01
- mucous membrane pemphigoid · score 0.01
- astrocytoma · score 0.01
- chronic kidney disease · score 0.01
- atypical teratoid rhabdoid tumor · score 0.01
- infection · score 0.01
- ventricular septal defect · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O94967-F1 | alphafold | PREDICTED | 66.86 | — |
Amino-acid sequence (919 residues)
MTAEETVNVK EVEIIKLILD FLNSKKLHIS MLALEKESGV INGLFSDDML FLRQLILDGQ WDEVLQFIQP LECMEKFDKK RFRYIILKQK FLEALCVNNA MSAEDEPQHL EFTMQEAVQC LHALEEYCPS KDDYSKLCLL LTLPRLTNHA EFKDWNPSTA RVHCFEEACV MVAEFIPADR KLSEAGFKAS NNRLFQLVMK GLLYECCVEF CQSKATGEEI TESEVLLGID LLCGNGCDDL DLSLLSWLQN LPSSVFSCAF EQKMLNIHVD KLLKPTKAAY ADLLTPLISK LSPYPSSPMR RPQSADAYMT RSLNPALDGL TCGLTSHDKR ISDLGNKTSP MSHSFANFHY PGVQNLSRSL MLENTECHSI YEESPERDTP VDAQRPIGSE ILGQSSVSEK EPANGAQNPG PAKQEKNELR DSTEQFQEYY RQRLRYQQHL EQKEQQRQIY QQMLLEGGVN QEDGPDQQQN LTEQFLNRSI QKLGELNIGM DGLGNEVSAL NQQCNGSKGN GSNGSSVTSF TTPPQDSSQR LTHDASNIHT STPRNPGSTN HIPFLEESPC GSQISSEHSV IKPPLGDSPG SLSRSKGEED DKSKKQFVCI NILEDTQAVR AVAFHPAGGL YAVGSNSKTL RVCAYPDVID PSAHETPKQP VVRFKRNKHH KGSIYCVAWS PCGQLLATGS NDKYVKVLPF NAETCNATGP DLEFSMHDGT IRDLAFMEGP ESGGAILISA GAGDCNIYTT DCQRGQGLHA LSGHTGHILA LYTWSGWMIA SGSQDKTVRF WDLRVPSCVR VVGTTFHGTG SAVASVAVDP SGRLLATGQE DSSCMLYDIR GGRMVQSYHP HSSDVRSVRF SPGAHYLLTG SYDMKIKVTD LQGDLTKQLP IMVVGEHKDK VIQCRWHTQD LSFLSSSADR TVTLWTYNG
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