About Rho guanine nucleotide exchange factor 15
Rho guanine nucleotide exchange factor 15 (ARHGEF15) is a protein
from Homo sapiens identified by UniProt accession
O94989, 841 residues long.
MolForge cross-references it against 0 known binders and
99 disease associations.
Target properties
| Protein name | Rho guanine nucleotide exchange factor 15 |
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| UniProt accession | O94989 |
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| Gene | ARHGEF15 |
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| Organism | Homo sapiens |
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| Length | 841 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (99)
Diseases linked to this target (Open Targets).
- developmental and epileptic encephalopathy · score 0.34
- hemoglobin measurement · score 0.29
- total cholesterol measurement · score 0.29
- BMI-adjusted waist-hip ratio · score 0.28
- hematocrit · score 0.28
- leukocyte count · score 0.27
- serum gamma-glutamyl transferase measurement · score 0.27
- platelet component distribution width · score 0.26
- low density lipoprotein cholesterol measurement · score 0.22
- lymphocyte count · score 0.22
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O94989-F1 | alphafold | PREDICTED | 61.55 | — |
Amino-acid sequence (841 residues)
MSAQSLPAAT PPTQKPPRII RPRPPSRSRA AQSPGPPHNG SSPQELPRNS NDAPTPMCTP IFWEPPAASL KPPALLPPSA SRASLDSQTS PDSPSSTPTP SPVSRRSASP EPAPRSPVPP PKPSGSPCTP LLPMAGVLAQ NGSASAPGTV RRLAGRFEGG AEGRAQDADA PEPGLQARAD VNGEREAPLT GSGSQENGAP DAGLACPPCC PCVCHTTRPG LELRWVPVGG YEEVPRVPRR ASPLRTSRSR PHPPSIGHPA VVLTSYRSTA ERKLLPLLKP PKPTRVRQDA TIFGDPPQPD LDLLSEDGIQ TGDSPDEAPQ NTPPATVEGR EEEGLEVLKE QNWELPLQDE PLYQTYRAAV LSEELWGVGE DGSPSPANAG DAPTFPRPPG PRNTLWQELP AVQASGLLDT LSPQERRMQE SLFEVVTSEA SYLRSLRLLT DTFVLSQALR DTLTPRDHHT LFSNVQRVQG VSERFLATLL SRVRSSPHIS DLCDVVHAHA VGPFSVYVDY VRNQQYQEET YSRLMDTNVR FSAELRRLQS LPKCERLPLP SFLLLPFQRI TRLRMLLQNI LRQTEEGSSR QENAQKALGA VSKIIERCSA EVGRMKQTEE LIRLTQRLRF HKVKALPLVS WSRRLEFQGE LTELGCRRGG VLFASRPRFT PLCLLLFSDL LLITQPKSGQ RLQVLDYAHR SLVQAQQVPD PSGPPTFRLS LLSNHQGRPT HRLLQASSLS DMQRWLGAFP TPGPLPCSPD TIYEDCDCSQ ELCSESSAPA KTEGRSLESR AAPKHLHKTP EGWLKGLPGA FPAQLVCEVT GEHERRRHLR QNQRLLEAVG SSSGTPNAPP P
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