Uridine phosphorylase 2 (UPP2)

About Uridine phosphorylase 2

Uridine phosphorylase 2 (UPP2) is a protein from Homo sapiens identified by UniProt accession O95045, 317 residues long. MolForge cross-references it against 0 known binders and 28 disease associations.

Target properties

Protein name	Uridine phosphorylase 2
UniProt accession	O95045
Gene	UPP2
Organism	Homo sapiens
Length	317 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (28)

Diseases linked to this target (Open Targets).

urate measurement · score 0.32
cutaneous melanoma · score 0.22
diffuse plaque measurement · score 0.11
diabetes mellitus · score 0.09
clear cell renal carcinoma · score 0.06
appendicular lean mass · score 0.05
birth weight · score 0.02
ganglion cell inner plexiform layer thickness measurement · score 0.02
neoplasm · score 0.01
acute lymphoblastic leukemia · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O95045-F1	alphafold	PREDICTED	92.70	—

Amino-acid sequence (317 residues)

MASVIPASNR SMRSDRNTYV GKRFVHVKNP YLDLMDEDIL YHLDLGTKTH NLPAMFGDVK FVCVGGSPNR MKAFALFMHK ELGFEEAEED IKDICAGTDR YCMYKTGPVL AISHGMGIPS ISIMLHELIK LLHHARCCDV TIIRIGTSGG IGIAPGTVVI TDIAVDSFFK PRFEQVILDN IVTRSTELDK ELSEELFNCS KEIPNFPTLV GHTMCTYDFY EGQGRLDGAL CSFSREKKLD YLKRAFKAGV RNIEMESTVF AAMCGLCGLK AAVVCVTLLD RLDCDQINLP HDVLVEYQQR PQLLISNFIR RRLGLCD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards