About Indolethylamine N-methyltransferase
Indolethylamine N-methyltransferase (INMT) is a protein
from Homo sapiens identified by UniProt accession
O95050, 263 residues long.
MolForge cross-references it against 0 known binders and
68 disease associations.
Target properties
| Protein name | Indolethylamine N-methyltransferase |
|---|
| UniProt accession | O95050 |
|---|
| Gene | INMT |
|---|
| Organism | Homo sapiens |
|---|
| Length | 263 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (68)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.27
- cystatin C measurement · score 0.20
- hypertension · score 0.20
- type 2 diabetes mellitus · score 0.12
- prostate carcinoma · score 0.11
- prostate cancer · score 0.11
- Familial prostate cancer · score 0.11
- hepatocellular carcinoma · score 0.09
- gastrointestinal disease · score 0.09
- Abnormality of the digestive system · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95050-F1 | alphafold | PREDICTED | 97.00 | — |
Amino-acid sequence (263 residues)
MKGGFTGGDE YQKHFLPRDY LATYYSFDGS PSPEAEMLKF NLECLHKTFG PGGLQGDTLI DIGSGPTIYQ VLAACDSFQD ITLSDFTDRN REELEKWLKK EPGAYDWTPA VKFACELEGN SGRWEEKEEK LRAAVKRVLK CDVHLGNPLA PAVLPLADCV LTLLAMECAC CSLDAYRAAL CNLASLLKPG GHLVTTVTLR LPSYMVGKRE FSCVALEKEE VEQAVLDAGF DIEQLLHSPQ SYSVTNAANN GVCFIVARKK PGP
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