About GTP-binding protein Di-Ras1
GTP-binding protein Di-Ras1 (DIRAS1) is a protein
from Homo sapiens identified by UniProt accession
O95057, 198 residues long.
MolForge cross-references it against 0 known binders and
32 disease associations.
Target properties
| Protein name | GTP-binding protein Di-Ras1 |
|---|
| UniProt accession | O95057 |
|---|
| Gene | DIRAS1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 198 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (32)
Diseases linked to this target (Open Targets).
- eosinophil count · score 0.17
- chronotype measurement · score 0.09
- renal cell carcinoma · score 0.08
- schizophrenia · score 0.07
- neoplasm · score 0.04
- cancer · score 0.04
- hypertension · score 0.03
- high density lipoprotein cholesterol measurement · score 0.02
- C-reactive protein measurement · score 0.02
- essential hypertension · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95057-F1 | alphafold | PREDICTED | 87.01 | — |
Amino-acid sequence (198 residues)
MPEQSNDYRV VVFGAGGVGK SSLVLRFVKG TFRDTYIPTI EDTYRQVISC DKSVCTLQIT DTTGSHQFPA MQRLSISKGH AFILVFSVTS KQSLEELGPI YKLIVQIKGS VEDIPVMLVG NKCDETQREV DTREAQAVAQ EWKCAFMETS AKMNYNVKEL FQELLTLETR RNMSLNIDGK RSGKQKRTDR VKGKCTLM
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