Fibrinogen silencer-binding protein (FSBP)

About Fibrinogen silencer-binding protein

Fibrinogen silencer-binding protein (FSBP) is a protein from Homo sapiens identified by UniProt accession O95073, 299 residues long. MolForge cross-references it against 0 known binders and 48 disease associations.

Target properties

Protein name	Fibrinogen silencer-binding protein
UniProt accession	O95073
Gene	FSBP
Organism	Homo sapiens
Length	299 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (48)

Diseases linked to this target (Open Targets).

Cleft palate · score 0.19
cleft lip · score 0.19
self reported educational attainment · score 0.18
neurodegenerative disease · score 0.16
macrothrombocytopenia, isolated, 2, autosomal dominant · score 0.07
thrombocytopenia 4 · score 0.06
autosomal dominant macrothrombocytopenia · score 0.05
beta-thalassemia-X-linked thrombocytopenia syndrome · score 0.05
waist circumference · score 0.05
platelet-type bleeding disorder 9 · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O95073-F1	alphafold	PREDICTED	69.48	—

Amino-acid sequence (299 residues)

MVGKARSSNF TLSEKLDLLK LVKPYVKILE EHTNKHSVIV EKNRCWDIIA VNYNAIGVDR PPRTAQGLRT LYKRLKEYAK QELLQQKETQ SDFKSNISEP TKKVMEMIPQ ISSFCLVRDR NHIQSANLDE EAQAGTSSLQ VMLDHHPVAI TVEVKQEEDI KPPPPLVLNS QQSDTLEQRE EHELVHVMER SLSPSLSSVD MRMTSSPSSI PRRDDFFRHE SGEHFRSLLG YDPQILQMLK EEHQIILENQ KNFGLYVQEK RDGLKRRQQL EEELLRAKIE VEKLKAIRLR HDLPEYNSL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards