Homeobox protein aristaless-like 3 (ALX3)

About Homeobox protein aristaless-like 3

Homeobox protein aristaless-like 3 (ALX3) is a protein from Homo sapiens identified by UniProt accession O95076, 343 residues long. MolForge cross-references it against 0 known binders and 96 disease associations.

Target properties

Protein name	Homeobox protein aristaless-like 3
UniProt accession	O95076
Gene	ALX3
Organism	Homo sapiens
Length	343 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (96)

Diseases linked to this target (Open Targets).

frontorhiny · score 0.79
frontonasal dysplasia · score 0.52
age at first sexual intercourse measurement · score 0.21
genetic disorder · score 0.19
cognitive function measurement · score 0.17
blood metabolite measurement · score 0.17
mathematical ability · score 0.16
self reported educational attainment · score 0.16
optic disc size measurement · score 0.12
cortical surface area measurement · score 0.12

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O95076-F1	alphafold	PREDICTED	61.51	—

Amino-acid sequence (343 residues)

MDPEHCAPFR VGPAPGPYVA SGDEPPGPQG TPAAAPHLHP APPRGPRLTR FPACGPLEPY LPEPAKPPAK YLQDLGPGPA LNGGHFYEGP AEAEEKTSKA ASFPQLPLDC RGGPRDGPSN LQGSPGPCLA SLHLPLSPGL PDSMELAKNK SKKRRNRTTF STFQLEELEK VFQKTHYPDV YAREQLALRT DLTEARVQVW FQNRRAKWRK RERYGKIQEG RNPFTAAYDI SVLPRTDSHP QLQNSLWASP GSGSPGGPCL VSPEGIPSPC MSPYSHPHGS VAGFMGVPAP SAAHPGIYSI HGFPPTLGGH SFEPSSDGDY KSPSLVSLRV KPKEPPGLLN WTT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards