About Arf-GAP domain and FG repeat-containing protein 2
Arf-GAP domain and FG repeat-containing protein 2 (AGFG2) is a protein
from Homo sapiens identified by UniProt accession
O95081, 481 residues long.
MolForge cross-references it against 0 known binders and
58 disease associations.
Target properties
| Protein name | Arf-GAP domain and FG repeat-containing protein 2 |
|---|
| UniProt accession | O95081 |
|---|
| Gene | AGFG2 |
|---|
| Organism | Homo sapiens |
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| Length | 481 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (58)
Diseases linked to this target (Open Targets).
- reticulocyte count · score 0.20
- mean reticulocyte volume · score 0.10
- mean corpuscular volume · score 0.10
- Blackfan-Diamond anemia · score 0.08
- reticulocyte measurement · score 0.08
- hereditary persistence of fetal hemoglobin-sickle cell disease syndrome · score 0.08
- high density lipoprotein cholesterol measurement · score 0.07
- alpha thalassemia-intellectual disability syndrome type 1 · score 0.07
- Alpha-thalassemia - intellectual disability syndrome linked to chromosome 16 · score 0.07
- delta-beta-thalassemia · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95081-F1 | alphafold | PREDICTED | 57.64 | — |
Amino-acid sequence (481 residues)
MVMAAKKGPG PGGGVSGGKA EAEAASEVWC RRVRELGGCS QAGNRHCFEC AQRGVTYVDI TVGSFVCTTC SGLLRGLNPP HRVKSISMTT FTEPEVVFLQ SRGNEVCRKI WLGLFDARTS LVPDSRDPQK VKEFLQEKYE KKRWYVPPDQ VKGPTYTKGS ASTPVQGSIP EGKPLRTLLG DPAPSLSVAA STSSQPVSQS HARTSQARST QPPPHSSVKK ASTDLLADIG GDPFAAPQMA PAFAAFPAFG GQTPSQGGFA NFDAFSSGPS SSVFGSLPPA GQASFQAQPT PAGSSQGTPF GATPLAPASQ PNSLADVGSF LGPGVPAAGV PSSLFGMAGQ VPPLQSVTMG GGGGSSTGLA FGAFTNPFTA PAAQSPLPST NPFQPNGLAP GPGFGMSSAG PGFPQAVPPT GAFASSFPAP LFPPQTPLVQ QQNGSSFGDL GSAKLGQRPL SQPAGISTNP FMTGPSSSPF ASKPPTTNPF L
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