Serine protease 23 (PRSS23)

About Serine protease 23

Serine protease 23 (PRSS23) is a protein from Homo sapiens identified by UniProt accession O95084, 383 residues long. MolForge cross-references it against 0 known binders and 104 disease associations.

Target properties

Protein name	Serine protease 23
UniProt accession	O95084
Gene	PRSS23
Organism	Homo sapiens
Length	383 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (104)

Diseases linked to this target (Open Targets).

Familial exudative vitreoretinopathy · score 0.56
Coats disease · score 0.42
Retinal dystrophy · score 0.38
intraocular pressure measurement · score 0.37
Norrie disease · score 0.34
forced expiratory volume · score 0.34
retinopathy of prematurity · score 0.33
FEV/FVC ratio · score 0.32
serum urea measurement · score 0.28
heel bone mineral density · score 0.27

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O95084-F1	alphafold	PREDICTED	81.30	—

Amino-acid sequence (383 residues)

MAGIPGLLFL LFFLLCAVGQ VSPYSAPWKP TWPAYRLPVV LPQSTLNLAK PDFGAEAKLE VSSSCGPQCH KGTPLPTYEE AKQYLSYETL YANGSRTETQ VGIYILSSSG DGAQHRDSGS SGKSRRKRQI YGYDSRFSIF GKDFLLNYPF STSVKLSTGC TGTLVAEKHV LTAAHCIHDG KTYVKGTQKL RVGFLKPKFK DGGRGANDST SAMPEQMKFQ WIRVKRTHVP KGWIKGNAND IGMDYDYALL ELKKPHKRKF MKIGVSPPAK QLPGGRIHFS GYDNDRPGNL VYRFCDVKDE TYDLLYQQCD AQPGASGSGV YVRMWKRQQQ KWERKIIGIF SGHQWVDMNG SPQDFNVAVR ITPLKYAQIC YWIKGNYLDC REG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards