About Homeobox protein Nkx-2.2
Homeobox protein Nkx-2.2 (NKX2-2) is a protein
from Homo sapiens identified by UniProt accession
O95096, 273 residues long.
MolForge cross-references it against 0 known binders and
151 disease associations.
Target properties
| Protein name | Homeobox protein Nkx-2.2 |
|---|
| UniProt accession | O95096 |
|---|
| Gene | NKX2-2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 273 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (151)
Diseases linked to this target (Open Targets).
- neonatal diabetes mellitus · score 0.37
- Abnormality of refraction · score 0.33
- chronotype measurement · score 0.30
- Ewing sarcoma · score 0.26
- type 2 diabetes mellitus · score 0.25
- head and neck squamous cell carcinoma · score 0.18
- genetic disorder · score 0.17
- cutaneous melanoma · score 0.11
- low grade glioma · score 0.10
- nose morphology measurement · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95096-F1 | alphafold | PREDICTED | 63.09 | — |
Amino-acid sequence (273 residues)
MSLTNTKTGF SVKDILDLPD TNDEEGSVAE GPEEENEGPE PAKRAGPLGQ GALDAVQSLP LKNPFYDSSD NPYTRWLAST EGLQYSLHGL AAGAPPQDSS SKSPEPSADE SPDNDKETPG GGGDAGKKRK RRVLFSKAQT YELERRFRQQ RYLSAPEREH LASLIRLTPT QVKIWFQNHR YKMKRARAEK GMEVTPLPSP RRVAVPVLVR DGKPCHALKA QDLAAATFQA GIPFSAYSAQ SLQHMQYNAQ YSSASTPQYP TAHPLVQAQQ WTW
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