Sphingosine 1-phosphate receptor 2 (S1PR2)

About Sphingosine 1-phosphate receptor 2

Sphingosine 1-phosphate receptor 2 (S1PR2) is a protein from Homo sapiens identified by UniProt accession O95136, 353 residues long. MolForge cross-references it against 0 known binders and 323 disease associations.

Target properties

Protein name	Sphingosine 1-phosphate receptor 2
UniProt accession	O95136
Gene	S1PR2
Organism	Homo sapiens
Length	353 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (2)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (323)

Diseases linked to this target (Open Targets).

multiple sclerosis · score 0.60
relapsing-remitting multiple sclerosis · score 0.59
reticulocyte count · score 0.55
reticulocyte measurement · score 0.53
deafness · score 0.53
hearing loss, autosomal recessive · score 0.52
monocyte count · score 0.51
leukocyte count · score 0.45
neutrophil count · score 0.40
serum alanine aminotransferase measurement · score 0.38

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O95136-F1	alphafold	PREDICTED	82.56	—

Amino-acid sequence (353 residues)

MGSLYSEYLN PNKVQEHYNY TKETLETQET TSRQVASAFI VILCCAIVVE NLLVLIAVAR NSKFHSAMYL FLGNLAASDL LAGVAFVANT LLSGSVTLRL TPVQWFAREG SAFITLSASV FSLLAIAIER HVAIAKVKLY GSDKSCRMLL LIGASWLISL VLGGLPILGW NCLGHLEACS TVLPLYAKHY VLCVVTIFSI ILLAIVALYV RIYCVVRSSH ADMAAPQTLA LLKTVTIVLG VFIVCWLPAF SILLLDYACP VHSCPILYKA HYFFAVSTLN SLLNPVIYTW RSRDLRREVL RPLQCWRPGV GVQGRRRGGT PGHHLLPLRS SSSLERGMHM PTSPTFLEGN TVV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards