About Mitofusin-2
Mitofusin-2 (MFN2) is a protein
from Homo sapiens identified by UniProt accession
O95140, 757 residues long.
MolForge cross-references it against 0 known binders and
455 disease associations.
Target properties
| Protein name | Mitofusin-2 |
|---|
| UniProt accession | O95140 |
|---|
| Gene | MFN2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 757 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (455)
Diseases linked to this target (Open Targets).
- Charcot-Marie-Tooth disease type 2A2 · score 0.82
- neuropathy, hereditary motor and sensory, type 6A · score 0.81
- Charcot-Marie-Tooth disease, axonal, autosomal recessive, type 2a2b; · score 0.81
- Autosomal dominant Charcot-Marie-Tooth disease type 2A2 · score 0.80
- hereditary motor and sensory neuropathy type 6 · score 0.63
- Charcot-Marie-Tooth disease type 2 · score 0.57
- multiple symmetric lipomatosis · score 0.54
- genetic disorder · score 0.54
- Charcot-Marie-Tooth disease · score 0.54
- severe early-onset axonal neuropathy due to MFN2 deficiency · score 0.45
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95140-F1 | alphafold | PREDICTED | 81.61 | — |
Amino-acid sequence (757 residues)
MSLLFSRCNS IVTVKKNKRH MAEVNASPLK HFVTAKKKIN GIFEQLGAYI QESATFLEDT YRNAELDPVT TEEQVLDVKG YLSKVRGISE VLARRHMKVA FFGRTSNGKS TVINAMLWDK VLPSGIGHTT NCFLRVEGTD GHEAFLLTEG SEEKRSAKTV NQLAHALHQD KQLHAGSLVS VMWPNSKCPL LKDDLVLMDS PGIDVTTELD SWIDKFCLDA DVFVLVANSE STLMQTEKHF FHKVSERLSR PNIFILNNRW DASASEPEYM EEVRRQHMER CTSFLVDELG VVDRSQAGDR IFFVSAKEVL NARIQKAQGM PEGGGALAEG FQVRMFEFQN FERRFEECIS QSAVKTKFEQ HTVRAKQIAE AVRLIMDSLH MAAREQQVYC EEMREERQDR LKFIDKQLEL LAQDYKLRIK QITEEVERQV STAMAEEIRR LSVLVDDYQM DFHPSPVVLK VYKNELHRHI EEGLGRNMSD RCSTAITNSL QTMQQDMIDG LKPLLPVSVR SQIDMLVPRQ CFSLNYDLNC DKLCADFQED IEFHFSLGWT MLVNRFLGPK NSRRALMGYN DQVQRPIPLT PANPSMPPLP QGSLTQEEFM VSMVTGLASL TSRTSMGILV VGGVVWKAVG WRLIALSFGL YGLLYVYERL TWTTKAKERA FKRQFVEHAS EKLQLVISYT GSNCSHQVQQ ELSGTFAHLC QQVDVTRENL EQEIAAMNKK IEVLDSLQSK AKLLRNKAGW LDSELNMFTH QYLQPSR
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