Dual specificity protein phosphatase 14 (DUSP14)

About Dual specificity protein phosphatase 14

Dual specificity protein phosphatase 14 (DUSP14) is a protein from Homo sapiens identified by UniProt accession O95147, 198 residues long. MolForge cross-references it against 0 known binders and 121 disease associations.

Target properties

Protein name	Dual specificity protein phosphatase 14
UniProt accession	O95147
Gene	DUSP14
Organism	Homo sapiens
Length	198 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (121)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.33
monocyte count · score 0.29
platelet count · score 0.28
leukocyte count · score 0.25
Parkinson disease · score 0.22
Alzheimer disease · score 0.22
lysosomal storage disease · score 0.22
multiple sclerosis · score 0.22
lymphocyte count · score 0.22
IGF-1 measurement · score 0.22

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O95147-F1	alphafold	PREDICTED	89.23	—

Amino-acid sequence (198 residues)

MSSRGHSTLP RTLMAPRMIS EGDIGGIAQI TSSLFLGRGS VASNRHLLQA RGITCIVNAT IEIPNFNWPQ FEYVKVPLAD MPHAPIGLYF DTVADKIHSV SRKHGATLVH CAAGVSRSAT LCIAYLMKFH NVCLLEAYNW VKARRPVIRP NVGFWRQLID YERQLFGKST VKMVQTPYGI VPDVYEKESR HLMPYWGI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards