Aldo-keto reductase family 7 member A3 (AKR7A3)

About Aldo-keto reductase family 7 member A3

Aldo-keto reductase family 7 member A3 (AKR7A3) is a protein from Homo sapiens identified by UniProt accession O95154, 331 residues long. MolForge cross-references it against 0 known binders and 40 disease associations.

Target properties

Protein name	Aldo-keto reductase family 7 member A3
UniProt accession	O95154
Gene	AKR7A3
Organism	Homo sapiens
Length	331 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (40)

Diseases linked to this target (Open Targets).

glioblastoma multiforme · score 0.13
hepatocellular carcinoma · score 0.09
blood protein measurement · score 0.08
neoplasm · score 0.08
urinary metabolite measurement · score 0.07
Barrett's esophagus · score 0.06
heel bone mineral density · score 0.05
bone quantitative ultrasound measurement · score 0.04
platelet crit · score 0.04
melorheostosis · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O95154-F1	alphafold	PREDICTED	96.51	—

Amino-acid sequence (331 residues)

MSRQLSRARP ATVLGAMEMG RRMDAPTSAA VTRAFLERGH TEIDTAFVYS EGQSETILGG LGLRLGGSDC RVKIDTKAIP LFGNSLKPDS LRFQLETSLK RLQCPRVDLF YLHMPDHSTP VEETLRACHQ LHQEGKFVEL GLSNYAAWEV AEICTLCKSN GWILPTVYQG MYNAITRQVE TELFPCLRHF GLRFYAFNPL AGGLLTGKYK YEDKNGKQPV GRFFGNTWAE MYRNRYWKEH HFEGIALVEK ALQAAYGASA PSMTSATLRW MYHHSQLQGA HGDAVILGMS SLEQLEQNLA AAEEGPLEPA VVDAFNQAWH LVTHECPNYF R

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards