About Neurexophilin-4
Neurexophilin-4 (NXPH4) is a protein
from Homo sapiens identified by UniProt accession
O95158, 308 residues long.
MolForge cross-references it against 0 known binders and
66 disease associations.
Target properties
| Protein name | Neurexophilin-4 |
|---|
| UniProt accession | O95158 |
|---|
| Gene | NXPH4 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 308 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (66)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.37
- body mass index · score 0.29
- IGF-1 measurement · score 0.19
- autosomal dominant compelling helio-ophthalmic outburst syndrome · score 0.17
- blood protein measurement · score 0.15
- eosinophil percentage of leukocytes · score 0.12
- balding measurement · score 0.11
- hepatocellular carcinoma · score 0.10
- eosinophil count · score 0.09
- cancer · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95158-F1 | alphafold | PREDICTED | 60.65 | — |
Amino-acid sequence (308 residues)
MRLLPEWFLL LFGPWLLRKA VSAQIPESGR PQYLGLRPAA AGAGAPGQQL PEPRSSDGLG VGRAWSWAWP TNHTGALARA GAAGALPAQR TKRKPSIKAA RAKKIFGWGD FYFRVHTLKF SLLVTGKIVD HVNGTFSVYF RHNSSSLGNL SVSIVPPSKR VEFGGVWLPG PVPHPLQSTL ALEGVLPGLG PPLGMAAAAA GPGLGGSLGG ALAGPLGGAL GVPGAKESRA FNCHVEYEKT NRARKHRPCL YDPSQVCFTE HTQSQAAWLC AKPFKVICIF VSFLSFDYKL VQKVCPDYNF QSEHPYFG
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