Zinc finger protein-like 1 (ZFPL1)

About Zinc finger protein-like 1

Zinc finger protein-like 1 (ZFPL1) is a protein from Homo sapiens identified by UniProt accession O95159, 310 residues long. MolForge cross-references it against 0 known binders and 68 disease associations.

Target properties

Protein name	Zinc finger protein-like 1
UniProt accession	O95159
Gene	ZFPL1
Organism	Homo sapiens
Length	310 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (68)

Diseases linked to this target (Open Targets).

pachyonychia congenita · score 0.07
essential tremor · score 0.07
Young adult-onset Parkinsonism · score 0.06
Hereditary late-onset Parkinson disease · score 0.06
optic atrophy 2 · score 0.06
Cranio-cervical dystonia with laryngeal and upper-limb involvement · score 0.06
X-linked dystonia-parkinsonism · score 0.06
X-linked parkinsonism-spasticity syndrome · score 0.05
spinocerebellar ataxia type 20 · score 0.05
torsion dystonia 2 · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O95159-F1	alphafold	PREDICTED	74.49	—

Amino-acid sequence (310 residues)

MGLCKCPKRK VTNLFCFEHR VNVCEHCLVA NHAKCIVQSY LQWLQDSDYN PNCRLCNIPL ASRETTRLVC YDLFHWACLN ERAAQLPRNT APAGYQCPSC NGPIFPPTNL AGPVASALRE KLATVNWARA GLGLPLIDEV VSPEPEPLNT SDFSDWSSFN ASSTPGPEEV DSASAAPAFY SQAPRPPASP GRPEQHTVIH MGNPEPLTHA PRKVYDTRDD DRTPGLHGDC DDDKYRRRPA LGWLARLLRS RAGSRKRPLT LLQRAGLLLL LGLLGFLALL ALMSRLGRAA ADSDPNLDPL MNPHIRVGPS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards