Gamma-aminobutyric acid receptor-associated protein…

About Gamma-aminobutyric acid receptor-associated protein

Gamma-aminobutyric acid receptor-associated protein (GABARAP) is a protein from Homo sapiens identified by UniProt accession O95166, 117 residues long. MolForge cross-references it against 0 known binders and 106 disease associations.

Target properties

Protein name	Gamma-aminobutyric acid receptor-associated protein
UniProt accession	O95166
Gene	GABARAP
Organism	Homo sapiens
Length	117 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (106)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.46
breast adenocarcinoma · score 0.18
birth weight · score 0.08
body height at birth · score 0.06
neutrophil percentage of leukocytes · score 0.06
alkaline phosphatase measurement · score 0.06
neoplasm · score 0.06
lymphocyte count · score 0.05
breast cancer · score 0.04
serum alanine aminotransferase measurement · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O95166-F1	alphafold	PREDICTED	94.93	—

Amino-acid sequence (117 residues)

MKFVYKEEHP FEKRRSEGEK IRKKYPDRVP VIVEKAPKAR IGDLDKKKYL VPSDLTVGQF YFLIRKRIHL RAEDALFFFV NNVIPPTSAT MGQLYQEHHE EDFFLYIAYS DESVYGL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Gamma-aminobutyric acid receptor-associated protein (GABARAP)