About NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial (NDUFB8) is a protein
from Homo sapiens identified by UniProt accession
O95169, 186 residues long.
MolForge cross-references it against 0 known binders and
275 disease associations.
Target properties
| Protein name | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial |
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| UniProt accession | O95169 |
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| Gene | NDUFB8 |
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| Organism | Homo sapiens |
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| Length | 186 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (275)
Diseases linked to this target (Open Targets).
- mitochondrial complex I deficiency · score 0.64
- type 2 diabetes mellitus · score 0.61
- polycystic ovary syndrome · score 0.61
- diabetes mellitus · score 0.60
- type 1 diabetes mellitus · score 0.58
- gestational diabetes · score 0.58
- obesity · score 0.57
- prediabetes syndrome · score 0.56
- schizophrenia · score 0.55
- insulin resistance · score 0.55
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95169-F1 | alphafold | PREDICTED | 87.83 | — |
Amino-acid sequence (186 residues)
MAVARAGVLG VQWLQRASRN VMPLGARTAS HMTKDMFPGP YPRTPEERAA AAKKYNMRVE DYEPYPDDGM GYGDYPKLPD RSQHERDPWY SWDQPGLRLN WGEPMHWHLD MYNRNRVDTS PTPVSWHVMC MQLFGFLAFM IFMCWVGDVY PVYQPVGPKQ YPYNNLYLER GGDPSKEPER VVHYEI
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