About F-box and WD repeat domain containing protein 10B
F-box and WD repeat domain containing protein 10B (FBXW10B) is a protein
from Homo sapiens identified by UniProt accession
O95170, 752 residues long.
MolForge cross-references it against 0 known binders and
4 disease associations.
Target properties
| Protein name | F-box and WD repeat domain containing protein 10B |
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| UniProt accession | O95170 |
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| Gene | FBXW10B |
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| Organism | Homo sapiens |
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| Length | 752 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (4)
Diseases linked to this target (Open Targets).
- diet measurement · score 0.04
- Colon Sessile Serrated Adenoma/Polyp · score 0.01
- sessile serrated polyp · score 0.00
- hepatocellular carcinoma · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95170-F1 | alphafold | PREDICTED | 67.88 | — |
Amino-acid sequence (752 residues)
MENLESRLKN APYFRCEKGT DSIPLCRKCE TRVLAWKIFS TKEWFCRIND ISQRRFLVGI LKQLNSLYLL HYFQNILQTT QGKDFIYNRS RIDLSKKEGK VVKSSLNQML DKTVEQKMKE ILYWFANSTQ WTKANYTLLL LQMCNPKLLL TAANVIRVLF LREENNISGL NQDITDVCFS PEKDHSSKSA TSQVYWTAKT QHTSLPLSKA PENEHFLGAA SNPEEPWRNS LRCISEMNRL FSGKADITKP GYDPCNLLVD LDDIRDLSSG FSKYRDFIRY LPIHLSKYIL RMLDRHTLNK CASVSQHWAA MAQQVKMDLS AHGFIQNQIT FLQGSYTRGI DPNYANKVSI PVPKMVDDGK SMRVKHPKWK LRTKNEYNLW TAYQNEETQQ VLMEERNVFC GTYNVRILSD TWDQNRVIHY SGGDLIAVSS NRKIHLLDII QVKAIPVEFR GHAGSVRALF LCEEENFLLS GSYDLSIRYW DLKSGVCTRI FGGHQGTITC MDLCKNRLVS GGRDCQVKVW DVDTGKCLKT FRHKDPILAT RINDTYIVSS CERGLVKVWH IAMAQLVKTL SGHEGAVKCL FFDQWHLLSG STDGLVMAWS MVGKYERCLM AFKHPKEVLD VSLLFLRVIS ACADGKIRIY NFFNGNCMKV IKANGRGDPV LSFFIQGNRI SVCHISTFAK RINVGWNGIE PSATAQGGNA SLTECAHVRL HIAGHLPASR LPVAAVQPMT GGMAPTTAPT HVLAMLILFS GV
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