NADH dehydrogenase [ubiquinone] 1 beta subcomplex…

About NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial (NDUFB2) is a protein from Homo sapiens identified by UniProt accession O95178, 105 residues long. MolForge cross-references it against 0 known binders and 231 disease associations.

Target properties

Protein name	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial
UniProt accession	O95178
Gene	NDUFB2
Organism	Homo sapiens
Length	105 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (231)

Diseases linked to this target (Open Targets).

type 2 diabetes mellitus · score 0.61
diabetes mellitus · score 0.60
polycystic ovary syndrome · score 0.60
type 1 diabetes mellitus · score 0.58
gestational diabetes · score 0.58
obesity · score 0.57
prediabetes syndrome · score 0.56
schizophrenia · score 0.56
insulin resistance · score 0.55
metabolic syndrome · score 0.53

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O95178-F1	alphafold	PREDICTED	71.67	—

Amino-acid sequence (105 residues)

MSALTRLASF ARVGGRLFRS GCARTAGDGG VRHAGGGVHI EPRYRQFPQL TRSQVFQSEF FSGLMWFWIL WRFWHDSEEV LGHFPYPDPS QWTDEELGIP PDDED

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial (NDUFB2)