Vesicle-associated membrane protein 5 (VAMP5)

About Vesicle-associated membrane protein 5

Vesicle-associated membrane protein 5 (VAMP5) is a protein from Homo sapiens identified by UniProt accession O95183, 116 residues long. MolForge cross-references it against 0 known binders and 104 disease associations.

Target properties

Protein name	Vesicle-associated membrane protein 5
UniProt accession	O95183
Gene	VAMP5
Organism	Homo sapiens
Length	116 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (104)

Diseases linked to this target (Open Targets).

lean body mass · score 0.36
body height · score 0.31
fat body mass · score 0.28
adolescent idiopathic scoliosis · score 0.26
base metabolic rate measurement · score 0.24
whole body water mass · score 0.24
appendicular lean mass · score 0.22
platelet component distribution width · score 0.21
serum gamma-glutamyl transferase measurement · score 0.20
reticulocyte count · score 0.18

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O95183-F1	alphafold	PREDICTED	79.81	—

Amino-acid sequence (116 residues)

MAGIELERCQ QQANEVTEIM RNNFGKVLER GVKLAELQQR SDQLLDMSST FNKTTQNLAQ KKCWENIRYR ICVGLVVVGV LLIILIVLLV VFLPQSSDSS SAPRTQDAGI ASGPGN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards