About Chondroitin sulfate proteoglycan 5
Chondroitin sulfate proteoglycan 5 (CSPG5) is a protein
from Homo sapiens identified by UniProt accession
O95196, 566 residues long.
MolForge cross-references it against 0 known binders and
49 disease associations.
Target properties
| Protein name | Chondroitin sulfate proteoglycan 5 |
|---|
| UniProt accession | O95196 |
|---|
| Gene | CSPG5 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 566 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (49)
Diseases linked to this target (Open Targets).
- reticulocyte count · score 0.30
- ovarian cancer · score 0.26
- Immature Reticulocyte Fraction Measurement · score 0.23
- cutaneous melanoma · score 0.20
- body mass index · score 0.16
- gastric adenocarcinoma · score 0.14
- smoking status measurement · score 0.12
- breast adenocarcinoma · score 0.11
- smoking initiation · score 0.09
- urate measurement · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95196-F1 | alphafold | PREDICTED | 51.86 | — |
Amino-acid sequence (566 residues)
MGRAGGGGPG RGPPPLLLFL GAALVLASGA VPAREAGSAV EAEELVKGSP AWEPPANDTR EEAGPPAAGE DEASWTAPGG ELAGPEEVLQ ESAAVTGTAW LEADSPGLGG VTAEAGSGDA QALPATLQAP HEVLGQSIMP PAIPEATEAS GPPSPTPGDK LSPASELPKE SPLEVWLNLG GSTPDPQGPE LTYPFQGTLE PQPASDIIDI DYFEGLDGEG RGADLGSFPG SPGTSENHPD TEGETPSWSL LDLYDDFTPF DESDFYPTTS FYDDLDEEEE EEEDDKDAVG GGDLEDENEL LVPTGKPGLG PGTGQPTSRW HAVPPQHTLG SVPGSSIALR PRPGEPGRDL ASSENGTECR SGFVRHNGSC RSVCDLFPSY CHNGGQCYLV ENIGAFCRCN TQDYIWHKGM RCESIITDFQ VMCVAVGSAA LVLLLLFMMT VFFAKKLYLL KTENTKLRRT NKFRTPSELH NDNFSLSTIA EGSHPNVRKL CNTPRTSSPH ARALAHYDNV ICQDDPSAPH KIQEVLKSCL KEEESFNIQN SMSPKLEGGK GDQADLDVNC LQNNLT
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