About Kelch-like protein 2
Kelch-like protein 2 (KLHL2) is a protein
from Homo sapiens identified by UniProt accession
O95198, 593 residues long.
MolForge cross-references it against 0 known binders and
298 disease associations.
Target properties
| Protein name | Kelch-like protein 2 |
|---|
| UniProt accession | O95198 |
|---|
| Gene | KLHL2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 593 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (298)
Diseases linked to this target (Open Targets).
- neuroticism measurement · score 0.25
- cognitive function measurement · score 0.23
- intelligence · score 0.22
- clear cell renal carcinoma · score 0.18
- self reported educational attainment · score 0.15
- acute myeloid leukemia · score 0.11
- infection · score 0.11
- infect · score 0.11
- mathematical ability · score 0.10
- Balkan nephropathy · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95198-F1 | alphafold | PREDICTED | 92.32 | — |
Amino-acid sequence (593 residues)
METPPLPPAC TKQGHQKPLD SKDDNTEKHC PVTVNPWHMK KAFKVMNELR SQNLLCDVTI VAEDMEISAH RVVLAACSPY FHAMFTGEMS ESRAKRVRIK EVDGWTLRML IDYVYTAEIQ VTEENVQVLL PAAGLLQLQD VKKTCCEFLE SQLHPVNCLG IRAFADMHAC TDLLNKANTY AEQHFADVVL SEEFLNLGIE QVCSLISSDK LTISSEEKVF EAVIAWVNHD KDVRQEFMAR LMEHVRLPLL PREYLVQRVE EEALVKNSSA CKDYLIEAMK YHLLPTEQRI LMKSVRTRLR TPMNLPKLMV VVGGQAPKAI RSVECYDFKE ERWHQVAELP SRRCRAGMVY MAGLVFAVGG FNGSLRVRTV DSYDPVKDQW TSVANMRDRR STLGAAVLNG LLYAVGGFDG STGLSSVEAY NIKSNEWFHV APMNTRRSSV GVGVVGGLLY AVGGYDGASR QCLSTVECYN ATTNEWTYIA EMSTRRSGAG VGVLNNLLYA VGGHDGPLVR KSVEVYDPTT NAWRQVADMN MCRRNAGVCA VNGLLYVVGG DDGSCNLASV EYYNPTTDKW TVVSSCMSTG RSYAGVTVID KPL
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