About RCC1 and BTB domain-containing protein 2
RCC1 and BTB domain-containing protein 2 (RCBTB2) is a protein
from Homo sapiens identified by UniProt accession
O95199, 551 residues long.
MolForge cross-references it against 0 known binders and
84 disease associations.
Target properties
| Protein name | RCC1 and BTB domain-containing protein 2 |
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| UniProt accession | O95199 |
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| Gene | RCBTB2 |
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| Organism | Homo sapiens |
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| Length | 551 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (84)
Diseases linked to this target (Open Targets).
- lymphocyte count · score 0.20
- birth weight · score 0.14
- creatinine measurement · score 0.12
- hematocrit · score 0.09
- hemoglobin measurement · score 0.08
- monocyte count · score 0.07
- erythroleukemia, familial, susceptibility to · score 0.06
- Mast Cell Sarcoma · score 0.05
- myofibromatosis, infantile, 1 · score 0.05
- tumor predisposition syndrome 2 · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95199-F1 | alphafold | PREDICTED | 90.43 | — |
Amino-acid sequence (551 residues)
MEEELPLFSG DSGKPVQATL SSLKMLDVGK WPIFSLCSEE ELQLIRQACV FGSAGNEVLY TTVNDEIFVL GTNCCGCLGL GDVQSTIEPR RLDSLNGKKI ACLSYGSGPH IVLATTEGEV FTWGHNAYSQ LGNGTTNHGL VPCHISTNLS NKQVIEVACG SYHSLVLTSD GEVFAWGYNN SGQVGSGSTV NQPIPRRVTG CLQNKVVVTI ACGQMCCMAV VDTGEVYVWG YNGNGQLGLG NSGNQPTPCR VAALQGIRVQ RVACGYAHTL VLTDEGQVYA WGANSYGQLG TGNKSNQSYP TPVTVEKDRI IEIAACHSTH TSAAKTQGGH VYMWGQCRGQ SVILPHLTHF SCTDDVFACF ATPAVTWRLL SVEPDDHLTV AESLKREFDN PDTADLKFLV DGKYIYAHKV LLKIRCEHFR SSLEDNEDDI VEMSEFSYPV YRAFLEYLYT DSISLSPEEA VGLLDLATFY RENRLKKLCQ QTIKQGICEE NAIALLSAAV KYDAQDLEEF CFRFCINHLT VVTQTSGFAE MDHDLLKNFI SKASRVGAFK N
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