About Mitochondrial proton/calcium exchanger protein
Mitochondrial proton/calcium exchanger protein (LETM1) is a protein
from Homo sapiens identified by UniProt accession
O95202, 739 residues long.
MolForge cross-references it against 0 known binders and
84 disease associations.
Target properties
| Protein name | Mitochondrial proton/calcium exchanger protein |
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| UniProt accession | O95202 |
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| Gene | LETM1 |
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| Organism | Homo sapiens |
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| Length | 739 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (84)
Diseases linked to this target (Open Targets).
- neurodegeneration, childhood-onset, with multisystem involvement due to mitochondrial dysfunction · score 0.73
- genetic disorder · score 0.19
- Neurodevelopmental disorder · score 0.19
- Wolf-Hirschhorn syndrome · score 0.13
- Global developmental delay · score 0.12
- ependymoma · score 0.11
- esophageal squamous cell carcinoma · score 0.08
- non-small cell lung carcinoma · score 0.08
- gonorrhea · score 0.08
- hepatocellular carcinoma · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95202-F1 | alphafold | PREDICTED | 66.59 | — |
Amino-acid sequence (739 residues)
MASILLRSCR GRAPARLPPP PRYTVPRGSP GDPAHLSCAS TLGLRNCLNV PFGCCTPIHP VYTSSRGDHL GCWALRPECL RIVSRAPWTS TSVGFVAVGP QCLPVRGWHS SRPVRDDSVV EKSLKSLKDK NKKLEEGGPV YSPPAEVVVK KSLGQRVLDE LKHYYHGFRL LWIDTKIAAR MLWRILNGHS LTRRERRQFL RICADLFRLV PFLVFVVVPF MEFLLPVAVK LFPNMLPSTF ETQSLKEERL KKELRVKLEL AKFLQDTIEE MALKNKAAKG SATKDFSVFF QKIRETGERP SNEEIMRFSK LFEDELTLDN LTRPQLVALC KLLELQSIGT NNFLRFQLTM RLRSIKADDK LIAEEGVDSL NVKELQAACR ARGMRALGVT EDRLRGQLKQ WLDLHLHQEI PTSLLILSRA MYLPDTLSPA DQLKSTLQTL PEIVAKEAQV KVAEVEGEQV DNKAKLEATL QEEAAIQQEH REKELQKRSE VAKDFEPERV VAAPQRPGTE PQPEMPDTVL QSETLKDTAP VLEGLKEEEI TKEEIDILSD ACSKLQEQKK SLTKEKEELE LLKEDVQDYS EDLQEIKKEL SKTGEEKYVE ESKASKRLTK RVQQMIGQID GLISQLEMDQ QAGKLAPANG MPTGENVISV AELINAMKQV KHIPESKLTS LAAALDENKD GKVNIDDLVK VIELVDKEDV HISTSQVAEI VATLEKEEKV EEKEKAKEKA EKEVAEVKS
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