About Protocadherin-8
Protocadherin-8 (PCDH8) is a protein
from Homo sapiens identified by UniProt accession
O95206, 1070 residues long.
MolForge cross-references it against 0 known binders and
102 disease associations.
Target properties
| Protein name | Protocadherin-8 |
|---|
| UniProt accession | O95206 |
|---|
| Gene | PCDH8 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 1070 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (102)
Diseases linked to this target (Open Targets).
- body mass index · score 0.29
- body fat percentage · score 0.23
- nasopharyngeal neoplasm · score 0.19
- MODY · score 0.11
- multisite chronic pain · score 0.10
- p-tau measurement · score 0.09
- type 2 diabetes mellitus · score 0.08
- papillary thyroid carcinoma · score 0.08
- unipolar depression · score 0.08
- esophageal squamous cell carcinoma · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95206-F1 | alphafold | PREDICTED | 69.68 | — |
Amino-acid sequence (1070 residues)
MSPVRRWGSP CLFPLQLFSL CWVLSVAQSK TVRYSTFEED APGTVIGTLA EDLHMKVSGD TSFRLMKQFN SSLLRVREGD GQLTVGDAGL DRERLCGQAP QCVLAFDVVS FSQEQFRLVH VEVEVRDVND HAPRFPRAQI PVEVSEGAAV GTRIPLEVPV DEDVGANGLQ TVRLAEPHSP FRVELQTRAD GAQCADLVLL QELDRESQAA YSLELVAQDG GRPPRSATAA LSVRVLDAND HSPAFPQGAV AEVELAEDAP VGSLLLDLDA ADPDEGPNGD VVFAFGARTP PEARRLFRLD PRSGRLTLAG PVDYERQDTY ELDVRAQDRG PGPRAATCKV IVRIRDVNDN APDIAITPLA APGAPATSPF AAAAAAAALG GADASSPAGA GTPEAGATSL VPEGAARESL VALVSTSDRD SGANGQVRCA LYGHEHFRLQ PAYAGSYLVV TAASLDRERI AEYNLTLVAE DRGAPPLRTV RPYTVRVGDE NDNAPLFTRP VYEVSVRENN PPGAYLATVA ARDRDLGRNG QVTYRLLEAE VGRAGGAVST YVSVDPATGA IYALRSFDYE TLRQLDVRIQ ASDGGSPQLS SSALVQVRVL DQNDHAPVLV HPAPANGSLE VAVPGRTAKD TVVARVQARD ADEGANGELA FELQQQEPRE AFAIGRRTGE ILLTGDLSQE PPGRVFRALL VISDGGRPPL TTTATVSFVV TAGGGRGPAA PASAGSPERS RPPGSRLGVS GSVLQWDTPL IVIIVLAGSC TLLLAAIIAI ATTCNRRKKE VRKGGALREE RPGAAGGGAS APGSPEEAAR GAGPRPNMFD VLTFPGTGKA PFGSPAADAP PPAVAAAEVP GSEGGSATGE SACHFEGQQR LRGAHAEPYG ASPGFGKEPA PPVAVWKGHS FNTISGREAE KFSGKDSGKG DSDFNDSDSD ISGDALKKDL INHMQSGLWA CTAECKILGH SDRCWSPSCS GPNAHPSPHP PAQMSTFCKS TSLPRDPLRR DNYYQAQLPK TVGLQSVYEK VLHRDYDRTV TLLSPPRPGR LPDLQEIGVP LYQSPPGRYL SPKKGANENV
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