About Epsin-2
Epsin-2 (EPN2) is a protein
from Homo sapiens identified by UniProt accession
O95208, 641 residues long.
MolForge cross-references it against 0 known binders and
27 disease associations.
Target properties
| Protein name | Epsin-2 |
|---|
| UniProt accession | O95208 |
|---|
| Gene | EPN2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 641 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (27)
Diseases linked to this target (Open Targets).
- diastolic blood pressure · score 0.31
- white matter hyperintensity measurement · score 0.21
- self reported educational attainment · score 0.20
- cortical thickness · score 0.19
- lung adenocarcinoma · score 0.18
- lymphocyte count · score 0.17
- schizophrenia · score 0.15
- neuritic plaque measurement · score 0.14
- lifestyle measurement · score 0.13
- intelligence · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95208-F1 | alphafold | PREDICTED | 59.10 | — |
Amino-acid sequence (641 residues)
MTTSSIRRQM KNIVNNYSEA EIKVREATSN DPWGPSSSLM TEIADLTYNV VAFSEIMSMV WKRLNDHGKN WRHVYKALTL LDYLIKTGSE RVAQQCRENI FAIQTLKDFQ YIDRDGKDQG INVREKSKQL VALLKDEERL KAERAQALKT KERMAQVATG MGSNQITFGR GSSQPNLSTS HSEQEYGKAG GSPASYHGSP EASLCPQHRT GAPLGQSEEL QPLSQRHPFL PHLGLASRPN GDWSQPCLTC DRAARATSPR VSSELEQARP QTSGEEELQL QLALAMSREV AEQEERLRRG DDLRLQMALE ESRRDTVKIP KKKEHGSLPQ QTTLLDLMDA LPSSGPAAQK AEPWGPSAST NQTNPWGGPA APASTSDPWP SFGTKPAASI DPWGVPTGAT VQSVPKNSDP WAASQQPASS AGKRASDAWG AVSTTKPVSV SGSFELFSNL NGTIKDDFSE FDNLRTSKKT AESVTSLPSQ NNGTTSPDPF ESQPLTVASS KPSSARKTPE SFLGPNAALV NLDSLVTRPA PPAQSLNPFL APGAPATSAP VNPFQVNQPQ PLTLNQLRGS PVLGTSTSFG PGPGVESMAV ASMTSAAPQP ALGATGSSLT PLGPAMMNMV GSVGIPPSAA QATGTTNPFL L
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