Leptin receptor overlapping transcript-like 1…

About Leptin receptor overlapping transcript-like 1

Leptin receptor overlapping transcript-like 1 (LEPROTL1) is a protein from Homo sapiens identified by UniProt accession O95214, 131 residues long. MolForge cross-references it against 0 known binders and 123 disease associations.

Target properties

Protein name	Leptin receptor overlapping transcript-like 1
UniProt accession	O95214
Gene	LEPROTL1
Organism	Homo sapiens
Length	131 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (123)

Diseases linked to this target (Open Targets).

FEV/FVC ratio · score 0.27
male infertility · score 0.20
hair colour measurement · score 0.20
breast carcinoma · score 0.20
acute myeloid leukemia · score 0.18
gastric carcinoma · score 0.18
gastric adenocarcinoma · score 0.18
colorectal adenocarcinoma · score 0.18
cutaneous melanoma · score 0.18
clear cell renal carcinoma · score 0.18

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O95214-F1	alphafold	PREDICTED	82.65	—

Amino-acid sequence (131 residues)

MAGIKALISL SFGGAIGLMF LMLGCALPIY NKYWPLFVLF FYILSPIPYC IARRLVDDTD AMSNACKELA IFLTTGIVVS AFGLPIVFAR AHLIEWGACA LVLTGNTVIF ATILGFFLVF GSNDDFSWQQ W

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Leptin receptor overlapping transcript-like 1 (LEPROTL1)