Zinc finger Ran-binding domain-containing protein 2…

About Zinc finger Ran-binding domain-containing protein 2

Zinc finger Ran-binding domain-containing protein 2 (ZRANB2) is a protein from Homo sapiens identified by UniProt accession O95218, 330 residues long. MolForge cross-references it against 0 known binders and 38 disease associations.

Target properties

Protein name	Zinc finger Ran-binding domain-containing protein 2
UniProt accession	O95218
Gene	ZRANB2
Organism	Homo sapiens
Length	330 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (38)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.56
body height · score 0.44
lysosomal storage disease · score 0.37
alcohol consumption measurement · score 0.30
age at menarche · score 0.28
sleep duration · score 0.27
intelligence · score 0.16
mathematical ability · score 0.12
alcohol use disorder measurement · score 0.11
cognitive function measurement · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O95218-F1	alphafold	PREDICTED	56.60	—

Amino-acid sequence (330 residues)

MSTKNFRVSD GDWICPDKKC GNVNFARRTS CNRCGREKTT EAKMMKAGGT EIGKTLAEKS RGLFSANDWQ CKTCSNVNWA RRSECNMCNT PKYAKLEERT GYGGGFNERE NVEYIEREES DGEYDEFGRK KKKYRGKAVG PASILKEVED KESEGEEEDE DEDLSKYKLD EDEDEDDADL SKYNLDASEE EDSNKKKSNR RSRSKSRSSH SRSSSRSSSP SSSRSRSRSR SRSSSSSQSR SRSSSRERSR SRGSKSRSSS RSHRGSSSPR KRSYSSSSSS PERNRKRSRS RSSSSGDRKK RRTRSRSPER RHRSSSGSSH SGSRSSSKKK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Zinc finger Ran-binding domain-containing protein 2 (ZRANB2)