Outer kinetochore KNL1 complex subunit ZWINT (ZWINT)

About Outer kinetochore KNL1 complex subunit ZWINT

Outer kinetochore KNL1 complex subunit ZWINT (ZWINT) is a protein from Homo sapiens identified by UniProt accession O95229, 277 residues long. MolForge cross-references it against 0 known binders and 97 disease associations.

Target properties

Protein name	Outer kinetochore KNL1 complex subunit ZWINT
UniProt accession	O95229
Gene	ZWINT
Organism	Homo sapiens
Length	277 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (97)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.53
total blood protein measurement · score 0.11
insomnia · score 0.11
hepatocellular carcinoma · score 0.10
breast cancer · score 0.09
attention deficit hyperactivity disorder · score 0.09
glioblastoma multiforme · score 0.08
schizophrenia 15 · score 0.07
attention deficit-hyperactivity disorder 8 · score 0.07
pachyonychia congenita · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O95229-F1	alphafold	PREDICTED	78.04	—

Amino-acid sequence (277 residues)

MEAAETEAEA AALEVLAEVA GILEPVGLQE EAELPAKILV EFVVDSQKKD KLLCSQLQVA DFLQNILAQE DTAKGLDPLA SEDTSRQKAI AAKEQWKELK ATYREHVEAI KIGLTKALTQ MEEAQRKRTQ LREAFEQLQA KKQMAMEKRR AVQNQWQLQQ EKHLQHLAEV SAEVRERKTG TQQELDRVFQ KLGNLKQQAE QERDKLQRYQ TFLQLLYTLQ GKLLFPEAEA EAENLPDDKP QQPTRPQEQS TGDTMGRDPG VSFKAVGLQP AGDVNLP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards