Apolipoprotein L3 (APOL3)

About Apolipoprotein L3

Apolipoprotein L3 (APOL3) is a protein from Homo sapiens identified by UniProt accession O95236, 402 residues long. MolForge cross-references it against 0 known binders and 38 disease associations.

Target properties

Protein name	Apolipoprotein L3
UniProt accession	O95236
Gene	APOL3
Organism	Homo sapiens
Length	402 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (38)

Diseases linked to this target (Open Targets).

serum alanine aminotransferase measurement · score 0.45
aspartate aminotransferase measurement · score 0.43
alkaline phosphatase measurement · score 0.43
glomerular filtration rate · score 0.41
leukocyte count · score 0.39
creatinine measurement · score 0.37
aspartate aminotransferase to alanine aminotransferase ratio · score 0.30
total blood protein measurement · score 0.30
hematocrit · score 0.20
lymphocyte count · score 0.17

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O95236-F1	alphafold	PREDICTED	59.32	—

Amino-acid sequence (402 residues)

MGLGQGWGWE ASCFACLIRS CCQVVTFTFP FGFQGISQSL ENVSGYYADA RLEVGSTQLR TAGSCSHSFK RSFLEKKRFT EEATKYFRER VSPVHLQILL TNNEAWKRFV TAAELPRDEA DALYEALKKL RTYAAIEDEY VQQKDEQFRE WFLKEFPQVK RKIQESIEKL RALANGIEEV HRGCTISNVV SSSTGAASGI MSLAGLVLAP FTAGTSLALT AAGVGLGAAS AVTGITTSIV EHSYTSSAEA EASRLTATSI DRLKVFKEVM RDITPNLLSL LNNYYEATQT IGSEIRAIRQ ARARARLPVT TWRISAGSGG QAERTIAGTT RAVSRGARIL SATTSGIFLA LDVVNLVYES KHLHEGAKSA SAEELRRQAQ ELEENLMELT QIYQRLNPCH TH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards