Lecithin retinol acyltransferase (LRAT)

About Lecithin retinol acyltransferase

Lecithin retinol acyltransferase (LRAT) is a protein from Homo sapiens identified by UniProt accession O95237, 230 residues long. MolForge cross-references it against 0 known binders and 170 disease associations.

Target properties

Protein name	Lecithin retinol acyltransferase
UniProt accession	O95237
Gene	LRAT
Organism	Homo sapiens
Length	230 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (2)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (170)

Diseases linked to this target (Open Targets).

Leber congenital amaurosis · score 0.76
retinitis pigmentosa · score 0.60
neurodegenerative disease · score 0.53
autosomal recessive retinitis pigmentosa · score 0.42
Posterior column ataxia - retinitis pigmentosa · score 0.41
severe early-childhood-onset retinal dystrophy · score 0.38
Leber congenital amaurosis 1 · score 0.35
Abnormality of the eye · score 0.34
Retinal dystrophy · score 0.33
Parkinson disease · score 0.26

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O95237-F1	alphafold	PREDICTED	83.30	—

Amino-acid sequence (230 residues)

MKNPMLEVVS LLLEKLLLIS NFTLFSSGAA GEDKGRNSFY ETSSFHRGDV LEVPRTHLTH YGIYLGDNRV AHMMPDILLA LTDDMGRTQK VVSNKRLILG VIVKVASIRV DTVEDFAYGA NILVNHLDES LQKKALLNEE VARRAEKLLG FTPYSLLWNN CEHFVTYCRY GTPISPQSDK FCETVKIIIR DQRSVLASAV LGLASIVCTG LVSYTTLPAI FIPFFLWMAG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards