About Methyl-CpG-binding domain protein 4
Methyl-CpG-binding domain protein 4 (MBD4) is a protein
from Homo sapiens identified by UniProt accession
O95243, 580 residues long.
MolForge cross-references it against 0 known binders and
106 disease associations.
Target properties
| Protein name | Methyl-CpG-binding domain protein 4 |
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| UniProt accession | O95243 |
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| Gene | MBD4 |
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| Organism | Homo sapiens |
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| Length | 580 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (106)
Diseases linked to this target (Open Targets).
- tumor predisposition syndrome 2 · score 0.62
- Uveal Melanoma · score 0.56
- Uveal melanoma · score 0.50
- acute myeloid leukemia · score 0.50
- colorectal cancer · score 0.49
- Inherited cancer-predisposing syndrome · score 0.27
- hereditary neoplastic syndrome · score 0.27
- genetic disorder · score 0.19
- breast adenocarcinoma · score 0.18
- serum gamma-glutamyl transferase measurement · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95243-F1 | alphafold | PREDICTED | 59.59 | — |
Amino-acid sequence (580 residues)
MGTTGLESLS LGDRGAAPTV TSSERLVPDP PNDLRKEDVA MELERVGEDE EQMMIKRSSE CNPLLQEPIA SAQFGATAGT ECRKSVPCGW ERVVKQRLFG KTAGRFDVYF ISPQGLKFRS KSSLANYLHK NGETSLKPED FDFTVLSKRG IKSRYKDCSM AALTSHLQNQ SNNSNWNLRT RSKCKKDVFM PPSSSSELQE SRGLSNFTST HLLLKEDEGV DDVNFRKVRK PKGKVTILKG IPIKKTKKGC RKSCSGFVQS DSKRESVCNK ADAESEPVAQ KSQLDRTVCI SDAGACGETL SVTSEENSLV KKKERSLSSG SNFCSEQKTS GIINKFCSAK DSEHNEKYED TFLESEEIGT KVEVVERKEH LHTDILKRGS EMDNNCSPTR KDFTGEKIFQ EDTIPRTQIE RRKTSLYFSS KYNKEALSPP RRKAFKKWTP PRSPFNLVQE TLFHDPWKLL IATIFLNRTS GKMAIPVLWK FLEKYPSAEV ARTADWRDVS ELLKPLGLYD LRAKTIVKFS DEYLTKQWKY PIELHGIGKY GNDSYRIFCV NEWKQVHPED HKLNKYHDWL WENHEKLSLS
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