About Interleukin-18 receptor accessory protein
Interleukin-18 receptor accessory protein (IL18RAP) is a protein
from Homo sapiens identified by UniProt accession
O95256, 599 residues long.
MolForge cross-references it against 0 known binders and
289 disease associations.
Target properties
| Protein name | Interleukin-18 receptor accessory protein |
|---|
| UniProt accession | O95256 |
|---|
| Gene | IL18RAP |
|---|
| Organism | Homo sapiens |
|---|
| Length | 599 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (289)
Diseases linked to this target (Open Targets).
- lymphocyte count · score 0.42
- eosinophil count · score 0.42
- Ascending aortic dissection · score 0.42
- eosinophil percentage of leukocytes · score 0.41
- atopic eczema · score 0.41
- celiac disease · score 0.38
- hepatitis C virus infection · score 0.37
- Eczematoid dermatitis · score 0.36
- Crohn's disease · score 0.34
- inflammatory bowel disease · score 0.33
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95256-F1 | alphafold | PREDICTED | 77.79 | — |
Amino-acid sequence (599 residues)
MLCLGWIFLW LVAGERIKGF NISGCSTKKL LWTYSTRSEE EFVLFCDLPE PQKSHFCHRN RLSPKQVPEH LPFMGSNDLS DVQWYQQPSN GDPLEDIRKS YPHIIQDKCT LHFLTPGVNN SGSYICRPKM IKSPYDVACC VKMILEVKPQ TNASCEYSAS HKQDLLLGST GSISCPSLSC QSDAQSPAVT WYKNGKLLSV ERSNRIVVDE VYDYHQGTYV CDYTQSDTVS SWTVRAVVQV RTIVGDTKLK PDILDPVEDT LEVELGKPLT ISCKARFGFE RVFNPVIKWY IKDSDLEWEV SVPEAKSIKS TLKDEIIERN IILEKVTQRD LRRKFVCFVQ NSIGNTTQSV QLKEKRGVVL LYILLGTIGT LVAVLAASAL LYRHWIEIVL LYRTYQSKDQ TLGDKKDFDA FVSYAKWSSF PSEATSSLSE EHLALSLFPD VLENKYGYSL CLLERDVAPG GVYAEDIVSI IKRSRRGIFI LSPNYVNGPS IFELQAAVNL ALDDQTLKLI LIKFCYFQEP ESLPHLVKKA LRVLPTVTWR GLKSVPPNSR FWAKMRYHMP VKNSQGFTWN QLRITSRIFQ WKGLSRTETT GRSSQPKEW
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