Growth arrest and DNA damage-inducible protein…

About Growth arrest and DNA damage-inducible protein GADD45 gamma

Growth arrest and DNA damage-inducible protein GADD45 gamma (GADD45G) is a protein from Homo sapiens identified by UniProt accession O95257, 159 residues long. MolForge cross-references it against 0 known binders and 264 disease associations.

Target properties

Protein name	Growth arrest and DNA damage-inducible protein GADD45 gamma
UniProt accession	O95257
Gene	GADD45G
Organism	Homo sapiens
Length	159 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (264)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.53
body mass index · score 0.45
body fat percentage · score 0.44
triglyceride measurement · score 0.43
mathematical ability · score 0.42
high density lipoprotein cholesterol measurement · score 0.41
hematocrit · score 0.41
asthma · score 0.41
hemoglobin measurement · score 0.41
vital capacity · score 0.40

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O95257-F1	alphafold	PREDICTED	87.93	—

Amino-acid sequence (159 residues)

MTLEEVRGQD TVPESTARMQ GAGKALHELL LSAQRQGCLT AGVYESAKVL NVDPDNVTFC VLAAGEEDEG DIALQIHFTL IQAFCCENDI DIVRVGDVQR LAAIVGAGEE AGAPGDLHCI LISNPNEDAW KDPALEKLSL FCEESRSVND WVPSITLPE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Growth arrest and DNA damage-inducible protein GADD45 gamma (GADD45G)