About Arginyl-tRNA--protein transferase 1
Arginyl-tRNA--protein transferase 1 (ATE1) is a protein
from Homo sapiens identified by UniProt accession
O95260, 518 residues long.
MolForge cross-references it against 0 known binders and
128 disease associations.
Target properties
| Protein name | Arginyl-tRNA--protein transferase 1 |
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| UniProt accession | O95260 |
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| Gene | ATE1 |
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| Organism | Homo sapiens |
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| Length | 518 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (128)
Diseases linked to this target (Open Targets).
- heel bone mineral density · score 0.46
- chronotype measurement · score 0.42
- bone quantitative ultrasound measurement · score 0.34
- breast carcinoma · score 0.29
- bone density · score 0.26
- Palmar Fibromatosis · score 0.26
- blood protein measurement · score 0.26
- age at menarche · score 0.23
- metabolite measurement · score 0.17
- neoplasm · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95260-F1 | alphafold | PREDICTED | 79.65 | — |
Amino-acid sequence (518 residues)
MAFWAGGSPS VVDYFPSEDF YRCGYCKNES GSRSNGMWAH SMTVQDYQDL IDRGWRRSGK YVYKPVMNQT CCPQYTIRCR PLQFQPSKSH KKVLKKMLKF LAKGEVPKGS CEDEPMDSTM DDAVAGDFAL INKLDIQCDL KTLSDDIKES LESEGKNSKK EEPQELLQSQ DFVGEKLGSG EPSHSVKVHT VPKPGKGADL SKPPCRKAKE IRKERKRLKL MQQNPAGELE GFQAQGHPPS LFPPKAKSNQ PKSLEDLIFE SLPENASHKL EVRVVRSSPP SSQFKATLLE SYQVYKRYQM VIHKNPPDTP TESQFTRFLC SSPLEAETPP NGPDCGYGSF HQQYWLDGKI IAVGVIDILP NCVSSVYLYY DPDYSFLSLG VYSALREIAF TRQLHEKTSQ LSYYYMGFYI HSCPKMKYKG QYRPSDLLCP ETYVWVPIEQ CLPSLENSKY CRFNQDPEAV DEDRSTEPDR LQVFHKRAIM PYGVYKKQQK DPSEEAAVLQ YASLVGQKCS ERMLLFRN
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