About Laforin
Laforin (EPM2A) is a protein
from Homo sapiens identified by UniProt accession
O95278, 331 residues long.
MolForge cross-references it against 0 known binders and
137 disease associations.
Target properties
| Protein name | Laforin |
|---|
| UniProt accession | O95278 |
|---|
| Gene | EPM2A |
|---|
| Organism | Homo sapiens |
|---|
| Length | 331 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (137)
Diseases linked to this target (Open Targets).
- myoclonic epilepsy of Lafora 1 · score 0.78
- Lafora disease · score 0.77
- Progressive myoclonic epilepsy · score 0.55
- genetic disorder · score 0.49
- neurodegenerative disease · score 0.42
- lobe attachment · score 0.41
- lysosomal storage disease · score 0.40
- multiple sclerosis · score 0.40
- Parkinson disease · score 0.40
- Alzheimer disease · score 0.40
Amino-acid sequence (331 residues)
MRFRFGVVVP PAVAGARPEL LVVGSRPELG RWEPRGAVRL RPAGTAAGDG ALALQEPGLW LGEVELAAEE AAQDGAEPGR VDTFWYKFLK REPGGELSWE GNGPHHDRCC TYNENNLVDG VYCLPIGHWI EATGHTNEMK HTTDFYFNIA GHQAMHYSRI LPNIWLGSCP RQVEHVTIKL KHELGITAVM NFQTEWDIVQ NSSGCNRYPE PMTPDTMIKL YREEGLAYIW MPTPDMSTEG RVQMLPQAVC LLHALLEKGH IVYVHCNAGV GRSTAAVCGW LQYVMGWNLR KVQYFLMAKR PAVYIDEEAL ARAQEDFFQK FGKVRSSVCS L
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