Potassium channel subfamily K member 5 (KCNK5)

About Potassium channel subfamily K member 5

Potassium channel subfamily K member 5 (KCNK5) is a protein from Homo sapiens identified by UniProt accession O95279, 499 residues long. MolForge cross-references it against 0 known binders and 135 disease associations.

Target properties

Protein name	Potassium channel subfamily K member 5
UniProt accession	O95279
Gene	KCNK5
Organism	Homo sapiens
Length	499 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (135)

Diseases linked to this target (Open Targets).

coronary artery disease · score 0.47
diastolic blood pressure · score 0.46
migraine disorder · score 0.43
body height · score 0.43
hemoglobin measurement · score 0.43
appendicular lean mass · score 0.41
hematocrit · score 0.41
myocardial infarction · score 0.40
erythrocyte count · score 0.40
hypertension · score 0.35

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O95279-F1	alphafold	PREDICTED	68.95	—

Amino-acid sequence (499 residues)

MVDRGPLLTS AIIFYLAIGA AIFEVLEEPH WKEAKKNYYT QKLHLLKEFP CLGQEGLDKI LEVVSDAAGQ GVAITGNQTF NNWNWPNAMI FAATVITTIG YGNVAPKTPA GRLFCVFYGL FGVPLCLTWI SALGKFFGGR AKRLGQFLTK RGVSLRKAQI TCTVIFIVWG VLVHLVIPPF VFMVTEGWNY IEGLYYSFIT ISTIGFGDFV AGVNPSANYH ALYRYFVELW IYLGLAWLSL FVNWKVSMFV EVHKAIKKRR RRRKESFESS PHSRKALQVK GSTASKDVNI FSFLSKKEET YNDLIKQIGK KAMKTSGGGE TGPGPGLGPQ GGGLPALPPS LVPLVVYSKN RVPTLEEVSQ TLRSKGHVSR SPDEEAVARA PEDSSPAPEV FMNQLDRISE ECEPWDAQDY HPLIFQDASI TFVNTEAGLS DEETSKSSLE DNLAGEESPQ QGAEAKAPLN MGEFPSSSES TFTSTESELS VPYEQLMNEY NKANSPKGT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards