About Vesicle-associated membrane protein-associated protein B/C
Vesicle-associated membrane protein-associated protein B/C (VAPB) is a protein
from Homo sapiens identified by UniProt accession
O95292, 243 residues long.
MolForge cross-references it against 0 known binders and
242 disease associations.
Target properties
| Protein name | Vesicle-associated membrane protein-associated protein B/C |
|---|
| UniProt accession | O95292 |
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| Gene | VAPB |
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| Organism | Homo sapiens |
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| Length | 243 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (242)
Diseases linked to this target (Open Targets).
- amyotrophic lateral sclerosis type 8 · score 0.71
- adult-onset proximal spinal muscular atrophy, autosomal dominant · score 0.65
- neurodegenerative disease · score 0.46
- amyotrophic lateral sclerosis · score 0.38
- Amyotrophic lateral sclerosis · score 0.38
- genetic disorder · score 0.19
- MODY · score 0.11
- axial length measurement · score 0.10
- appendicular lean mass · score 0.09
- type 2 diabetes mellitus · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95292-F1 | alphafold | PREDICTED | 76.86 | — |
Amino-acid sequence (243 residues)
MAKVEQVLSL EPQHELKFRG PFTDVVTTNL KLGNPTDRNV CFKVKTTAPR RYCVRPNSGI IDAGASINVS VMLQPFDYDP NEKSKHKFMV QSMFAPTDTS DMEAVWKEAK PEDLMDSKLR CVFELPAEND KPHDVEINKI ISTTASKTET PIVSKSLSSS LDDTEVKKVM EECKRLQGEV QRLREENKQF KEEDGLRMRK TVQSNSPISA LAPTGKEEGL STRLLALVVL FFIVGVIIGK IAL
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