NADH dehydrogenase [ubiquinone] 1 subunit C2 (NDUFC2)

About NADH dehydrogenase [ubiquinone] 1 subunit C2

NADH dehydrogenase [ubiquinone] 1 subunit C2 (NDUFC2) is a protein from Homo sapiens identified by UniProt accession O95298, 119 residues long. MolForge cross-references it against 0 known binders and 240 disease associations.

Target properties

Protein name	NADH dehydrogenase [ubiquinone] 1 subunit C2
UniProt accession	O95298
Gene	NDUFC2
Organism	Homo sapiens
Length	119 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (240)

Diseases linked to this target (Open Targets).

mitochondrial complex 1 deficiency, nuclear type 36 · score 0.69
type 2 diabetes mellitus · score 0.61
diabetes mellitus · score 0.60
polycystic ovary syndrome · score 0.60
type 1 diabetes mellitus · score 0.58
gestational diabetes · score 0.58
obesity · score 0.57
prediabetes syndrome · score 0.56
schizophrenia · score 0.55
insulin resistance · score 0.55

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O95298-F1	alphafold	PREDICTED	90.92	—

Amino-acid sequence (119 residues)

MIARRNPEPL RFLPDEARSL PPPKLTDPRL LYIGFLGYCS GLIDNLIRRR PIATAGLHRQ LLYITAFFFA GYYLVKREDY LYAVRDREMF GYMKLHPEDF PEEDKKTYGE IFEKFHPIR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards