About 6-phosphogluconolactonase
6-phosphogluconolactonase (PGLS) is a protein
from Homo sapiens identified by UniProt accession
O95336, 258 residues long.
MolForge cross-references it against 0 known binders and
19 disease associations.
Target properties
| Protein name | 6-phosphogluconolactonase |
|---|
| UniProt accession | O95336 |
|---|
| Gene | PGLS |
|---|
| Organism | Homo sapiens |
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| Length | 258 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (19)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.33
- lymphocyte count · score 0.03
- leukocyte count · score 0.03
- atopic eczema · score 0.02
- hepatocellular carcinoma · score 0.02
- myeloid white cell count · score 0.02
- ovarian carcinoma · score 0.02
- glioblastoma multiforme · score 0.02
- Alzheimer disease · score 0.01
- glioblastoma · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95336-F1 | alphafold | PREDICTED | 94.85 | — |
Amino-acid sequence (258 residues)
MAAPAPGLIS VFSSSQELGA ALAQLVAQRA ACCLAGARAR FALGLSGGSL VSMLARELPA AVAPAGPASL ARWTLGFCDE RLVPFDHAES TYGLYRTHLL SRLPIPESQV ITINPELPVE EAAEDYAKKL RQAFQGDSIP VFDLLILGVG PDGHTCSLFP DHPLLQEREK IVAPISDSPK PPPQRVTLTL PVLNAARTVI FVATGEGKAA VLKRILEDQE ENPLPAALVQ PHTGKLCWFL DEAAARLLTV PFEKHSTL
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